Me in the ICC clinic when we get an unexpected negative genetic test:

Does maternal tadalafil a phosphodiesterase inhibitor increase placental perfusion to treat fetal growth restriction? MRI shows IV tadalafil does not increase uterine artery blood flow or fetal O2 delivery Jack Darby UniSA Biomedical Engineering & Imaging Sciences UCL-IfWH
physoc.onlinelibrary.wiley.com/doi/10.1113/EP…

Version v0.10.0 of the MendelianRandomization package is currently making its way to CRAN. Two major new functions: mr_clr implements weak instrument robust methods outlined in onlinelibrary.wiley.com/doi/10.1111/bi… (Anderson–Rubin, Kleibergen, and the conditional likelihood ratio test), ...

Genetic variation is relatively poorly studied in the Middle East, particularly where endogamy and consanguinity are more common. Among 6K WGS in Qatar, 2 in 3 (!) was a carrier for a pathogenic mutation for an autosomal recessive condition. link.springer.com/article/10.118……

Honoured to be awarded this opportunity & excited to continue researching ways to improve outcomes for women who experience hypertension in pregnancy in low and middle income countries, alongside an amazing & expanding team!🌍

Come and work with us at KCL! PhD studentship opportunity to assess the impact of gestational diabetes on markers of fetal adiposity. Appropriate for students with a background of antenatal ultrasound proficiency kcl.ac.uk/study-legacy/f…

Countless individuals are born with heart or lung conditions, and Royal Brompton and Harefield hospitals play an incredible role in supporting them through life's journey. That's why we're committed to giving back and funding vital research to enhance their impact even further.

Lots of enthusiasm about Impella for post-MI shock but there's a possibility it may not benefit women. Merits further assessment. It's also among the reasons why trials need to be broadly inclusive. nejm.org/doi/full/10.10… NEJM #ACC2024 Women as One

Immensely proud to be appointed as a Trustee of the Royal Brompton & Harefield Hospitals Charity.

Excited to be able to support Royal Brompton & Harefield Hospitals Charity's mission to advance the care for heart and lung patients through research and innovation!

rbhcharity.org/governance-team

📢 Mavacamten has been approved in Scotland for the treatment of obstructive HCM 📢

Mavacamten, the first ever drug specifically for a type of cardiomyopathy, has been approved for use in Scotland.

Learn more:

📲 cardiomyopathy.org/news-blogs/lat…

Less than full-time is the new normal in paediatric training in the UK

LTFT permitted for any trainee since 2022
Hospitals need to adapt to new reality

Lauren Dhugga
adc.bmj.com/content/early/…

A great day for the KHP Inherited Cardiac Conditions team and our very many patients and families, as we welcome the wonderful Dr Stefania Rosmini to our service King's College NHS!
🫀🧬🧲☢
Stefania Rosmini Elizabeth Wilson Rachel Bastiaenen Dr Tootie Bueser💙 AICC

'Pre-eclampsia in our local language, we don’t have it, it’s not there' Our 'Lost in Translation' Study published today explores language barriers to informed consent in Zambia: important lessons for global health researchers & ethics committees BMJ_Open bmjopen.bmj.com/panels_ajax_ta…

A great day for the KHP Inherited Cardiac Conditions team and our very many patients and families, as we welcome the wonderful Dr Stefania Rosmini to our service King's College NHS!
🫀🧬🧲☢
Stefania Rosmini Elizabeth Wilson Rachel Bastiaenen Dr Tootie Bueser💙 AICC

🎯 All measures of LA structure & function predicted CV death/hHF except LA conduit strain
🎯 LAVImin was the best predictor
🎯 Patients with highest tercile LAVmin had similar event rate to patients in AF
🎯 LA strain did not enhance model precision

Delighted to present our study comparing the prognostic power of different measures of left atrial structure and function in dilated cardiomyopathy #EJHJCI European Society of Cardiology Journals

doi.org/10.1093/ehjci/…

Further info in🧵⬇️

Great to have this preprint out - In 50k CMRs of the UK Biobank, we identified common and rare genetic factors influencing trabeculation, identified modifiers, and assessed the relationship with cardiomyopathies and imaging-derived traits. Declan O'Regan medrxiv.org/cgi/content/sh…

Pre-eclampsia associated differences in the placenta, fetal brain and maternal heart can be demonstrated antenatally: An observational cohort study using MRI Antonio de Marvao @dancromb Lisa Story Jana Hutter Pablo Lamata (CMIB) Lucy Chappell

ahajournals.org/doi/10.1161/HY…

Now online at Hypertension
👇
ahajournals.org/doi/10.1161/HY…

This pilot study was a true 'labor of love' (no pun intended) that we hope will lead to larger studies - still much we don't understand about 🫀 effects of 🤰

🧵 of primary findings attached 👇

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Great News for International Medical Graduates (IMGs):

An 'Advisory Commission on Alternative Licensing Model' has been set up to offer advice on state licensing for IMGs who have completed their training abroad.

This means they will be able to practice in the USA (under…