Merci au journal Le Monde & Pascale Santi pour cet article sur le programme Ariane destiné aux ados avec maladies chroniques proposant un parcours coordonné pour éviter les ruptures de soins. Défis & espoirs HCL - Hospices Civils de Lyon Hôpitaux Nord-Ouest #ado #RareDiseases dlvr.it/T5xbvH

Thank you Belot Alexandre for outstanding grand round and stimulating research discussions during the visiting professorship at the Univ. Children's Hospital Ljubljana 🇨🇵🇸🇮👏🤝

🆕 C'est en ligne ! Nous retrouvons Dr Isabelle MELKI pour la web conférence du mois de juin : Treat to Target dans le #lupus pédiatrique 🩺 T2T en pédiatrie : outils de mesure & objectifs, recos thérapeutiques & perspectives 👉 fai2r.org/videotheque-pa… #maladiesrares #JeudisFAI2R

🤔 What would you like to learn/hear about? Our Tuesday Lunch with RITA webinars are open to suggestions! We are interested in hearing about your ideas 🤗 ⬇ bit.ly/4cgi7dG

Well done Marie Louise and team, important informations on monogenic lupus !

How to treat monogenic SLE? Personalized therapies discussion. sciencedirect.com/science/articl… Jade Cognard

6 novel monoallelic PTPN2 mutations in pediatric lupus and Evans syndrome that cause T cell hyperproliferation and high inflammatory cytokines JExpMed doi.org/10.1084/jem.20… Megan Cooper comment doi.org/10.1084/jem.20… Belot Alexandre Frederic Rieux-Laucat #Mathieu

Jeanpierre, Cognard, Frederic Rieux-Laucat, Belot Alexandre, Mathieu CIRI Lyon et al. performed exome sequencing in pediatric systemic #lupus and Evans syndrome and identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. hubs.la/Q02HrHBb0 #autoimmunity

JExpMed Belot Alexandre CIRI Lyon A nice and fruitful collaboration between teams of Belot Alexandre CIRI Lyon and Frederic Rieux-Laucat Institut Imagine showing that dysregulation of the JAK/STAT pathway as a consequence of PTPN2 deficiency leads to a new Primary Immune Deficiency and Dysregulation (PIDD).

Haploinsufficiency in PTPN2 leads to early-onset systemic #autoimmunity from Evans syndrome to #lupus, say Marie Jeanpierre (@JEANPIERRMarie), Jade Cognard (Jade Cognard), Frédéric Rieux-Laucat Frederic Rieux-Laucat, Belot Alexandre, Anne-Laure Mathieu & colleagues hubs.la/Q02HvkMP0

PTPN2 deficiency: Amping up JAK/STAT. Joshua Tobin and Megan Cooper Megan Cooper Test Account discuss study from Marie Jeanpierre, Jade Cognard, Frederic Rieux-Laucat, Belot Alexandre, Mathieu and colleagues (hubs.la/Q02HrXdq0): hubs.la/Q02HrFLB0

Findings from @JEANPIERRMarie, Jade Cognard, Frederic Rieux-Laucat, Belot Alexandre et al. suggest that PTPN2 along with SOCS1 haploinsufficiency constitute a new group of monogenic autoimmune diseases that can benefit from targeted therapy. hubs.la/Q02Hvg8z0 #lupus #autoimmunity

Incredible discovery. Also very informative for users of TNFa blockers!

Fantastic findings, very elegant! Well done Petter and Co. 👏👏