He is sharing a recent Clinical Cancer Research study showing that immunological profiling of #irAEs with #ImmuneCheckpointInhibitors reveals actionable targets for #PrecisionMedicine -based interventions. aacrjournals.org/clincancerres/… #IOTNCapstoneMeeting

Cracking the Genomic Code of CDK4/6 Inhibitor Resistance.
bit.ly/3wF5rOb

Polo-like Kinase 1 Inhibition in KRAS-Mutated Metastatic #ColorectalCancer .
bit.ly/4dFkCHT

Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study.
bit.ly/3wrP0oz

Molecular and Pathologic Characterization of YAP1-Expressing Small Cell Lung Cancer Cell Lines Leads to Reclassification as SMARCA4-Deficient Malignancies.
bit.ly/3yhfMk2

Platinum-Based #Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade.
bit.ly/4bi90ci

Randomized Phase II Trial of Imiquimod with or without 9-Valent #HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147).
bit.ly/3WIKo8g

Update on Cancer Predisposition Syndromes and Surveillance Guidelines for Childhood Brain Tumors. bit.ly/3UJBBA6

FDA Approval Summary: Ciltacabtagene Autoleucel for Relapsed or Refractory Multiple Myeloma - via Clinical Cancer Research pubmed.ncbi.nlm.nih.gov/38713595/

#OCEPublications

Myeloma Paper of the Day, May 11st, suggested by Robert Z. Orlowski
MD Anderson Cancer Center Clinical Cancer Research Lorraine Davis Jordan Lab Peter Forsberg MD Daniel Sherbenou, MD, PhD
oncodaily.com/63730.html

#Cancer #MM #Cancer Research #OncoDaily #Oncology

.Julie Miller & team at 🥼 Massachusetts General Hospital discovered that isocitrate dehydrogenase (IDH)-mutant #gliomas with deletion of CDKN2A/B were sensitized to CDK4/6 ⛔ inhibitors.

😎 Check it out in Clinical Cancer Research!

🔗 bit.ly/3WCr2Se

1/4 Congrats to Ana Aparicio and team on this adaptive, investigator-initiated trial of 192 men with mCRPC Clinical Cancer Research ! shorturl.at/uwAFS  All men got 8 weeks of AAPA. Based on PSA decline at 8 weeks, went on to add ipi, continue AAPA, or add cabazi/carbo

Researchers from Mass General Cancer Center and colleagues investigated a combination drug therapy for advanced solid tumors, in a Clinical Cancer Research study. doi.org/10.1158/1078-0…

⭐️Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies AACR Clinical Cancer Research Cancer Research Communications aacrjournals.org/cancerrescommu…

A must-📖 commentary by Natasha Rekhtman MD PhD on our recent Clinical Cancer Research paper 👇 #SCLC Jin Ng, PhD Marian Burr

FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced #Melanoma .
bit.ly/3QJC2cz

Immunotherapy after chemotherapy may be the right choice - Piotr Wysocki
Uniwersytet Jagielloński Clinical Cancer Research Daniel McManus Maria Andrea Cardenas Suresh S. Ramalingam, MD, FASCO Ehsan Ghorani Haydn Kissick Zach Buchwald MD PhD
oncodaily.com/62427.html

#Cancer #Cancer Research #OncoDaily #Oncology

REGISTER NOW! for our 2-part webinar series on QUALITY DEFECTS AND METHODS OF REPRODUCIBILITY IN BIOMEDICAL RESEARCH May 14 & 21. For more information and to register, visit fnlm.org/product/qualit…

Belzutifan for von Hippel–Lindau Disease: #Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
bit.ly/4dx6Yqd