Cancer Discovery
@cd_aacr
Follow Cancer Discovery for high-impact articles and news covering major advances in basic, translational, and clinical cancer research. Published by @AACR.
ID: 1021485047977832449
http://cancerdiscovery.aacrjournals.org/ 23-07-2018 19:59:48
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Now online in Cancer Discovery: #MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in #BreastCancer - by Jitendra K Meena, Trey Westbrook and colleagues doi.org/10.1158/2159-8… BCMHouston
From the August issue: Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. bit.ly/3yN4ip3 Gabriele Picco Mathew Garnett Garnett Lab Wellcome Sanger Institute
From the August issue: BRCA1-mediated Dual Regulation of #Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-inhibition in BRCA1-deficient Cancers. bit.ly/3T7n0P0 Guang Lei, Boyi Gan, PhD and colleagues MD Anderson Cancer Center
Another interesting paper today - congrats to Garnett Lab - this target came out of a gwCRISPR screen in MSI cell lines. No one expected it so it is great to see a small molecule inhibitor have an effect, particularly in IO resistant lines!
From the August issue: ZNF397 Deficiency Triggers TET2-driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Ping Mu 🇺🇦 PCF Science UTSW Simmons Cancer Center. bit.ly/3MqdTVP
Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, Liling Wan, and colleagues. Penn Medicine Penn Medicine - Abramson Cancer Center Penn Epigenetics Univ. of Pennsylvania Department of Cancer Biology bit.ly/4cTwIvw
Friends! I am super-excited to share our story on KLHL6 in this @BCD_aacr 📣KLHL6 targets the B-cell receptor and lymphoma mutations perturb this homeostasis! 🔓Read doi.org/10.1158/2643-3… 🪩Joint editorial in Cancer Discovery doi.org/10.1158/2159-8… 🧵Let’s go
I'm super excited to see our work featured on the cover art of the September issue of Cancer Discovery Cancer Discovery. aacrjournals.org/cancerdiscover… Artwork by Bianca Dunn