Long-term kidney allograft survival is hampered by interstitial fibrosis & tubular atrophy. This study found spironolactone added to standard therapy in transplant patients did not improve kidney function, long-term proteinuria, or interstitial fibrosis bit.ly/CJASN0439

Blood purification by dialysis is a nephrology cornerstone. This Perspective provides an update on current knowledge on hemoadsorption and describes its current use and research agenda for the future bit.ly/CJASN0433

Lui Forni

Nonlupus full house nephropathy is a rare, complex entity. This study supports that SLE and nonlupus full house nephropathy are distinct clinical entities, with comparable outcomes bit.ly/CJASN0438

Andreas Kronbichler

Primary hyperoxaluria is a family of rare, autosomal recessive disorders. This article emphasizes the utility of genetic testing in routine diagnostic evaluation of patients suspected of having primary hyperoxaluria and at-risk family members bit.ly/CJASN0460

Long interdialytic interval in thrice-weekly hemodialysis is associated with excess cardiovascular and all-cause mortality risk. This study found the 3-day interval was associated with further impairment of VO2 at peak exercise bit.ly/CJASN0435

Noninfectious, nonmechanical complications often present late in patients who are established on PD. This article discusses abnormal-appearing drained dialysate, encapsulating peritoneal sclerosis, and metabolic changes associated with PD bit.ly/CJASN0418

Frequent monitoring & early individualization of PD prescriptions are prerequisites for delivery of high-quality PD. This study found most patients in the US were prescribed nocturnal PD only with limited variability across the first 4 months of therapy bit.ly/CJASN0436

Peritoneal dialysis (PD) offers flexibility and autonomy to patients with ESKD. This article covers mechanical complications of PD, including leaks, PD hydrothorax, hernias, dialysate flow problems, PD-related pain, and changes in respiratory mechanics bit.ly/CJASN0417

Lowering dialysate sodium concentration may improve volume & BP control in patients on maintenance hemodialysis. This study found use of a dialysate sodium concentration of 135 was linked to a small reduction in interdialytic weight gain bit.ly/CJASN0431

Dan Weiner

There have been scarce epidemiologic data on the relationship between inflammatory bowel disease and the incidence of IgA nephropathy. This study shows the potential association of inflammatory bowel disease with higher risk of developing IgA nephropathy bit.ly/CJASN0457

AKI secondary to light chain cast nephropathy is common in patients with multiple myeloma. This article presents an approach to this problem, including the requirement for prompt diagnosis, immediate anti-myeloma treatment, and high-quality supportive care bit.ly/CJASN0400

It has been suggested that the beneficial effects observed in the intensive systolic BP-lowering group in SPRINT were due to differential use of diuretics. This study shows these effects were independent of and not mediated by time-varying diuretics use bit.ly/CJASN0406

Liddle syndrome is a rare form of monogenic hypertension caused by gain-of-function variants in the epithelial Na+ channel (ENaC). This study found patients with genetically confirmed Liddle syndrome displayed a phenotypic spectrum bit.ly/CJASN0430

This study shows the Home Dialysis Care Experience survey, a newly developed 26-item measure that includes one composite scale and two global rating scores, is an informative tool to evaluate patient experience of care for home dialysis bit.ly/CJASN0429

Wael Hussein

Despite its numerous advantages, PD utilization has been static or diminishing. This article describes the definition, epidemiology, risk factors, prevention, and treatment of PD-related infection on the basis of the contemporary evidence bit.ly/CJASN0280

David W Johnson

This study found the Mayo Imaging Classification, developed to predict disease progression in patients with ADPKD, showed acceptable stability & generally predicted kidney failure & eGFR decline. However, there was variability within each class bit.ly/CJASN0427

Preclinical models of disease suggest targeting microRNA-21 may slow the decline in kidney function in individuals with Alport syndrome. This study found no improvement in rate of kidney function decline after anti-microRNA-21 therapy with lademirsen bit.ly/CJASN0458

Clinical trials are underway to evaluate novel agents targeting the alternative complement pathway in patients with C3G. Kidney Health Initiative's C3G Trial Endpoints Work Group assessed prespecified endpoints as measures of clinical benefit in these trials bit.ly/CJASN0505

Attention American Society of Nephrology members: Kidney Week meeting abstracts from 2000 to the present are now freely available in the JASN_News content archive! For more information, visit bit.ly/MeetingAbstrac…