Centre for Medicines Discovery
@cmdoxford
A multi-disciplinary Institute within the University of Oxford which focuses upon translational activities to catalyse the discovery of new medicines.
ID: 1281511219413876738
https://www.cmd.ox.ac.uk/ 10-07-2020 08:51:45
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The Centre for Medicines Discovery team in New York this week for the ASAP Discovery meeting. What a privilege to at last hang out with the people in person we were in the trenches with since COVID Moonshot. And getting to know all the new people joining our pandemic preparedness effort.
Join us for the upcoming Target 2035 #webinar to expand your knowledge and contribute to the advancement of best practices for #chemicalprobes. Mark your 📅 and register for #free: bit.ly/3MAAobz WEHI (Walter and Eliza Hall Institute), Cell Signalling Laboratory, University of Sydney, Centre for Drug Discovery Innovation, Nature Communications
The Bullock lab @CMDOxford has a new paper on KEAP1-CUL3 structure, TR-FRET and inhibition by CDDO. Great collaboration with Ralph Mazitschek Ralph Mazitschek DOI: doi.org/10.1016/j.free…
Congratulations to all CMD team members of the COVID Moonshot collaboration that was awarded the 2nd place in the SCI innovation award! Great to see the project recognised amongst a very competitive field at a ceremony in the Palace of Westminster last Wednesday.
The Katharina L. Duerr and David B Sauer group's new publication reveals export of immunoregulatory sphingosine-1-phosphate is regulated by the signaling lipid PIP2 via its action on the transporter SPNS2. doi.org/10.1016/j.molc…
The Bullock lab @CMDOxford and Wilkie Lab Wilkie Lab report a new paper identifying mutations in the BTB domain of KCTD15 that perturb BTB oligomerisation and cause a distinctive frontonasal dysplasia syndrome DOI: doi.org/10.1136/jmg-20…
New publication on the structure and allosteric regulation of Alzheimer’s target SHIP1 from Will Bradshaw, Opher Gileadi, Oxford Drug Discovery Institute, Kavli Institute for Nanoscience Discovery, Oxford. Including an XChem fragment screen with 91 structures. authors.elsevier.com/sd/article/S09…
Congratulations to team PROTECT, including our own Prof Frank von Delft, on receiving the Cancer Grand Challenges Challenges award! They're tackling the tough challenge of #SolidTumours in children Cancer Research UK, National Cancer Institute cmd.ox.ac.uk/news/research-…
🎉The Chemical Probes Portal has reached 1,000 compounds! We review hundreds of high-quality protein inhibitors and other tools for biomedical research, as well as 255 Unsuitables. Read more: chemicalprobes.org/news/1000-comp… #OpenScience #DrugDiscovery #TPD #degraders #ChemicalProbes
The Bullock lab at Centre for Medicines Discovery together with Ontario Institute for Cancer Research (OICR) and M4K Pharma report in J Med Chem the Discovery of Conformationally Constrained ALK2 Inhibitors aimed at future treatments for the childhood brain tumour DIPG. Congratulations Julien Cros, Jong Fu Wong and Dr Melissa Sweeney
ACS Publications Bio & Med Chem Content New scaffold to explore ADP-ribose metabolism: By performing SAR studies, we identify a first-in-class, non-covalent dual inhibitor for NUDT5 and NUDT14. (5/5) 📖Read the full story here: pubs.acs.org/doi/10.1021/ac… #CovalentInhibitors #ChemicalProbes #DarkProteome
The Bullock group at Centre for Medicines Discovery and Alison Axtman at Structural Genomics Consortium (SGC) report the first chemical probe for the CDKL2 kinase providing an important reagent to interrogate CDKL2-dependent biology. pubs.acs.org/doi/10.1021/ac…
Revealing Cationic Amino acid Transporter 1 (CAT1) selectivity and binding to Friend Murine Leukemia Virus. Collab of Mingda Ye, David B Sauer, Benedikt Kessler, Centre for Medicines Discovery, STRUBIOxford, CAMS Oxford Institute, and im2pact doi.org/10.21203/rs.3.…