Miss the PILOT trial result livestream on Monday night?

Full recording is available here
➡️ criticalcarereviews.com/livestreams/pi…

🔴 Superb results presentation
🔴 Excellent discussion on the robustness & implications of the trial from world leading experts

criticalcarereviews.com/livestreams/pi…

Here's my comparison of the 2 vasodilator scavengers used for vasopressor refractory distributive shock:
🟥hydrocobalamin vs 🟦methylene blue

Which has more evidence? What are the pros/cons?

If you want to learn more I'll be giving a talk on this at #ResusX next week! #FOAMed

.Aleks Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and #ARDS and explore the larger challenge of clinical research on therapies for syndromes with profound clinical and biologic heterogeneity. eviden.cc/3gzcks0

#CritCare

Lots of big trials released this week

Struggling to stay up-to-date with the literature?

We've listed the major trials published so far this year

criticalcarereviews.com/latest-evidenc…

8th European Conference on Rehabiliation and Weaning in Critically Ill Patients
Belfast, April 22-23, 2023

Abstract deadline: Jan 27
Early bird rate: Feb 28
20% for groups of 4+
Thanks to bronwen connolly an team for organizing this exciting event

aSAH phase II RCT
➡️conservative (induced hypertension) vs endovascular Rx (IA nimodipine or balloon angioplasty)

🚩limitations
➡️small
➡️terminated early
➡️limited Rx details
➡️50% clipped
➡️not blinded (neuroradiologist blinded)

CCR Journal Watch
criticalcarereviews.com/latest-evidenc…

Results of the landmark #SuDDICU trial showing benefits of selective decontamination of the digestive tract in critically ill patients are out, presented by our John Myburgh AO at ESICM session in Paris and published in JAMA!
Details:
georgeinstitute.org/media-releases…

Today's Paper of the Day is by Elvina Elizabeth Lius on hyperoxia in the management of respiratory failure

criticalcarereviews.com/latest-evidenc…

#criticalcare #intensivecare #ICU #FOAMed #FOAMEDcc #MedTwitter

Nice review on high flow nasal oxygen therapy

➡️ type 1 failure - hypoxia
➡️ type 2 failure - hypercapnoea
➡️ type 3 failure - atelectasis / post-operative
➡️ type 4 failure - muscular failure (hypoperfusion from shock)

CCR Journal Watch
criticalcarereviews.com/latest-evidenc…

ESPNIC clinical practice guidelines: IV maintenance fluid therapy in acute & critically ill children

PICO1 — Indication
PICO2 — Tonicity
PICO3 — Balanced fluids
PICO4 — Composition
PICO5 — Amounts:

Stay up-to-date with the critical care literature
criticalcarereviews.com/latest-evidenc…

Targeted Temperature Management in Postresuscitation Care After Incorporating Results of the TTM2 Trial

➡️cooling techniques
➡️landmark trials

🚩cooling
➡️impact
➡️initiation
➡️duration
➡️complications

Stay up-to-date with the critical care literature
criticalcarereviews.com/latest-evidenc…

Today's Paper of the Day is by Michael Pinsky on effective hemodynamic monitoring

criticalcarereviews.com/latest-evidenc…

#criticalcare #intensivecare #ICU #FOAMed #FOAMEDcc #MedTwitter

Paul Young Mega-ROX Bharath Kumar If you go back to sleep you will wake up with the #megarox completed (target 40,000 patients for those who still do not know)

the Critical Care Reviews event and @nejm publication of yesterday probably triggered 02 research enthusiasm worldwide #PILOTtrial by Pragmatic Critical Care Research Group

Following today's presentation at ESICM & publication in JAMA , here is the full 97 minute SuDDICU presentation at CCR22 in June.

This includes the background, methods, results, SRMA, editorial, viewer's questions and panel discussion.

criticalcarereviews.com

Critical Care Reviews always there to share important trials

A supplemental Critical Care Reviews Newsletter containing links to the major publications from today's ESICM 2022 Congress Hot Topics Session, is now out

criticalcarereviews.com/newsletters/cu…

Today's Paper of the Day is by Ângelo Zambam de Mattos on albumin administration in patients with cirrhosis: current role and novel perspectives

criticalcarereviews.com/latest-evidenc…

#criticalcare #intensivecare #ICU #FOAMed #FOAMEDcc #MedTwitter

🧵 on NIV in #ARDS 🫁

I’ve seen A LOT of inappropriate use of NIV in #COVID19 & have often ranted about it on Twitter. There’s also lot of new data on NIV that’s been inconsistent & confusing.

Let’s break some of it down. I’ll also add in some highlights from #LIVES2022