A key question in #microbiome is how a protein expression depends on how essential it is to microbial growth or ability to claim resources. Wang and Li cleverly combined #metagenomics and #metaproteomics to address this question. NorthOmics lab Leyuan Li academic.oup.com/ismecommun/art…

We are thrilled to share our new paper in ISME Communications by Wang & Li et al. We have developed a novel pipeline to characterize a protein’s functional role in microbial ecosystems by pairing metagenomic & metaproteomic data Tong Daniel Figeys Yang Liu A THREAD (1/8)

🔍We define 3 types of functions to categorize: 1) Specialist function: specialized by only a few taxa; 2) Niche function: selectively expressed under specific conditions; 3) Essential function: metabolically indispensable and widespread across many taxa within a community.(2/8)

It's fascinating to see the shift from 16S rRNA sequencing to #metagenomics, both relying on function prediction. While it is a natural progression, integrating #metaproteomics will provide a more accurate representation of #microbiome biology. NorthOmics lab

Assays are fundamental to drug development. We previously developed RapidAIM, a 96-well plate ex vivo assay for human microbiomes. Discover the power of RapidAIM 2.0 for your drug screening needs! #DrugDevelopment #Microbiome NorthOmics lab oaepublish.com/articles/mrr.2…

Conventional #metaproteomics β-diversity metrics ignore protein interrelationships in microbiomes. Check out PhyloFunc by Drs. L. Wang & team Daniel Figeys Leyuan Li, a new metric that incorporates phylogeny for improved functional ecological insights. biorxiv.org/content/10.110…

Check out MetaLab for DIA for metaproteomics without the need for DDA!

Interested to do #metaproteomics using DIA mass spectrometry, while being free from generating DDA results? Check out the new version of MetaLab-DIA imetalab.ca. #FreefromDDA Zhibin Ning NorthOmics lab

I'm thrilled to share our new #Bioconductor package, nipalsMCIA, which performs multi-omic dimensionality reduction using the NIPALS algorithm. It is fast (especially for large datasets), and user friendly. Give it a try! biorxiv.org/content/10.110… (1/4)

Ruedi Aebersold ETH Zürich and Matthias Mann Max Planck Institute of Biochemistry (MPIB) have been awarded the Dr H.P. Heineken Prize for Biochemistry and Biophysics 2024 for their groundbreaking contributions to the field proteomics. Congratulations, well-deserved! heinekenprizes.org/2024/06/11/rue…

🌟Exciting News! We're thrilled to announce the MRR 2023 Best Paper Award: First Prize: Prof. Jens Walter 's team Second Prize: Prof. Willem M. de Vos's team Third Prize: Prof. Daniel Figeys' team View more details via:👇 oaepublish.com/news/mrr.820 Congratulations to them! 🙌

New Research Alert!😍 🧐Assessing #fecal #metaproteomics workflow and small #protein recovery using #DDA and #DIA PASEF #massspectrometry 🧐This study underscores the critical impact of experimental choices on metaproteomic outcomes View: 🫱oaepublish.com/articles/mrr.2… Daniel Figeys

🚨Newest work from our lab & Yang Lab to advance host-directed therapy for #tuberculosis. We improved the activity, cytotoxicity & bioavailability of our phosphatase inhibitor, resulting in improved efficacy for #TB HDT! UBC Dept of Microbiology and Immunology UBC Life Sciences Institute pubs.acs.org/doi/10.1021/ac…

In situ targeted base editing of bacteria in the mouse gut | Nature nature.com/articles/s4158…