Does the future of #insulin therapy #diabetes encompass apamer-based selective insulin receptor modulation? Nature Communications nature.com/articles/s4146…

More data using mouse genetics implicates a role for the arcuate nucleus GLP-1R in the control of feeding link.springer.com/article/10.118…

Daniel J Drucker Molecular Metabolism Interesting.
However, Fasudil, a ROCK inhibitor is licensed in Japan for the treatment of vasospasms following subarachnoid hemorrhage since 1995. No signal of clinically relevant hyperglycemia in any of the studies. Activation of ROCK likely to worsen HTN, glaucoma, and IR.

Here the authors propose from studies of #islets cell lines and mice that ROCK1 is a positive regulator of insulin secretion and developing small molecules for its activation may offer unexplored approaches to treating #diabetes Molecular Metabolism sciencedirect.com/science/articl…

Modest goals for #microbiota medicines “Monitoring and managing the intestinal microbiota may represent a next-generation medicine able to tackle or reduce the litany of chronic diseases and a pivotal component of personalized medicine” Trends in Microbiology cell.com/trends/microbi…

It was clear to some that taking Twitter private was secretly being financed by Big Carbohydrate & now the #diet community must learn to live with the new reality. Hang in there, low CHO Keto folks, regroup, and bring forth your best long term RCTs to defeat the new CHO prophet

While NBA and Joe Tsai use stern words to condemn (multiple) antisemitic posts, the actual consequences for Kyrie Irving to spread hate speech and conspiracy theories are zilch, natta, nothing. Cause words are cheap, and profits trump the cost of meaningful ethical behaviour

Everyone loves a “causal association” Here “Physical activity enhances #vaccine effectiveness against severe #COVID19 outcomes” Or if you are healthy, and can #exercise regularly, well you resist severe illness relative to the more infirm sedentary folks bjsm.bmj.com/content/early/…

New #EndocrineReviews The molecular rationale for HIF2α blockade with a focus on neuroendocrine tumors academic.oup.com/edrv/advance-a…

Based on induction of browning and thermogenesis in mouse adipocytes it is concluded that maneuvers targeting Salt inducible kinase 3 (SIKs) could be beneficial for #obesity and related metabolic disease biorxiv.org/content/10.110…

More nonenzymatic pro-inflammatory roles of DPP4 in impairing Treg function, here through IGF2R metabolismjournal.com/article/S0026-…

Marco knows that tweeting about the contents of an article, based on titles and abstracts, even in a scientific Journal, is risky, unless one actually reads the article first. Resist temptation, don’t be that Marco

Or, if one scrutinizes the available experimental data carefully, we can surmise that there is no rigorous evidence linking GCGR activation to enhancement of inflammation. Class B GPCR activation and cAMP generation is generally anti-inflammatory

Native GLP-1 acutely improves endothelial function.Degradation-resistant GLP-1RA and DPP-4 inhibitors? Not so much dom-pubs.onlinelibrary.wiley.com/doi/10.1111/do…

The spatiotemporal landscape of lactate metabolism in health and disease Cell Metabolism cell.com/cell-metabolis…

Interestingly, the authors make extensive use of HepG2 cells, an immortalized cell line that does not express the canonical GCGR, to study the anti- inflammatory actions of glucagon