KRYSAL-12; Ada v doce in G12C; #ESMO24

Great to see the UK RWE dataset on adjuvant osimertinib presented at #ESMO24. Led by Tom Newsom-Davis. I was delighted to meet the 3 Imperial College London medical students involved in this work. They were rightly overwhelmed by the majesty of a premier global cancer conference. Well done

Abst 1248P; LAURA; Chinese cohort. Abysmal control arm confirmed in Chinese cohort; no at risk at 33m is zero; #ESMO24

Abst 1387P; RWE sotorasib in NSCLC G12C; data from UK; great to see our Kent data included led by Heba Hassan. Good to see the data is concordance with randomised trials #ESMO24

#ESMO24 pharma hall Sunday 0740; empty

ARTEMIS; automated AI guided tumour response assessment in #mesothelioma ; almost perfect correlation between AI and radiologist; #ESMO24

LAURA; update on CNS and distant PD; PFS HR 0.16 irrespective of PET ; clear signal in terms of protection of brain and extra-cranial sites #ESMO24

ALINA; Foundation 1CDx biomarker evaluation; 81% EML4-; benefit across all EML4 variants; TP53 mutations = lower DFS on alectinib #ESMO24

POTENTIAL; Neoadjuvant nivo in high risk Stage 1 resectable NSCLC; 3x2w infusions pre op. N52; An impressive pCR 23% MPR 46%; no unexpected AE’s; #ESMO24 ; an excellent and clinically relevant hypothesis generating study

Nice summary slide by Heather Wakelee; this is a huge amount of data in a short period of time; where we are with SACT in early lung cancer #ESMO24

NEJ034; LUNG cancer with IPF; perfenidone to prevent post op AE; 4% reduction in AE; primary EP not met #ESMO24

Can inhaled corticosteroid reduce RT induced lung damage during radical lung rt for unresectable IIIa/b?; n292; yes it can. 15% reduction in radiation pneumonitis. #ESMO24 lovely trial; practice changing #ESMO24

JCOG1914 : weekly low dose carbo taxol vs carbo only with radical RT; single agent wins. No efficacy benefit with toxicity detriment. #ESMO24

AMG 193 in MTAP deleted rumours. Important trial. Should be part of work up for many thoracic malignancies #ESMO24