"Early levodopa initiation in #Parkinsons does neither postpone nor accelerate mortality or PD-related complications, nor does it precipitate earlier occurrence of PD-related complications or mortality" …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Data in 8,300 PD GENEration study patients found 12.9% with Parkinson's-linked gene variants, including those with no known risk factors. parkinsonsnewstoday.com/news/genetic-t…

Walthamstow said no to racism

"A good #mentor, identification of a niche, and patience are the three important aspects for an aspiring neurologist." Discover more early-career advice for #neurologists in this interview with Kailash Bhatia, Professor of Clinical Neurology, @UCL: hubs.la/Q02KPhQ00

Lionel Ginsberg pays tribute to Richard Orrell, who died unexpectedly in May, while travelling. He was 64 years old and had worked for more than 25 years as a consultant neurologist. acnr.co.uk/articles/obitu…

*Attention Healthcare Professionals and people living with Dystonia!* We're conducting an important survey of people living with Dystonia in the UK to explore their experiences of Physiotherapy. Take the survey here: qualtrics.ucl.ac.uk/jfe/form/SV_0T…

📢Please share our dystonia survey! We would like to reach people living with Dystonia in the UK and sample their experiences of physiotherapy. Open for two months from today!

Dr. Rauan Kaiyrzhanov advocates for establishing a national brain biobank in Kazakhstan to advance research on neurodegenerative diseases like Parkinson's and Alzheimer's. UCL Queen Square Institute of Neurology UCL Brain Sciences michaeljfox.org Central Asian & Transcaucasian Genomics (CATG) Rauan Kaiyrzhanov Read more: bit.ly/4dGq24w

#CryoEM structures of tau filaments of individuals with P301T or P301L mutations reveal novel folds, suggesting that models with such mutations should be used with caution in the study of sporadic tauopathies, such as #Alzheimers. With Michel Goedert. biorxiv.org/content/10.110…

FTDP-17 mutations P301L and P301T in MAPT give rise to novel tau filament folds. Individuals with mutations of P301 have distinct tauopathies. Great work: Manuel Schweighauser, Yang Shi, Alexey Murzin. As always with Sjors Scheres. biorxiv.org/content/10.110…

Our work on blood-based inflammation markers in FTLD is published! We found a pro-inflammatory cytokine profile in patients that is associated with central inflammation and worse survival outcomes. Huge thanks to all families, colleagues and funders! academic.oup.com/brain/advance-…

Excited to share our correspondence in The Lancet Neurology, reporting updates from the CAT-PD project, which investigates Parkinson's disease genetics in Central Asia & Transcaucasia.Central Asian & Transcaucasian Genomics (CATG) UCL Brain Sciences michaeljfox.org The Neurogenetics Lab ION UCL Global Engagement bit.ly/46PJU37

Congratulations to our CAT-PD project member Dr Mariam Isayan, a neurologist and GP2 trainee from Armenia for receiving the GP2 Under-represented Populations Master's Program scholarship to undertake studies in Data Science at the University of Maryland Baltimore County. UCL Queen Square Institute of Neurology

Juvenile generic parkinsonism. academic.oup.com/brain/article/…

Andrew Lees Ed Jabbari dear movement disorder neurologists - do you see any clinical use at present for synuclein RT-QuIC (excluding research projects)

Delighted to share our paper on the selective degradation of aggregated tau. JoJo Benn and Shi Cheng used nanobodies against tau, and fused them to the catalytic RING domain of clustering-activated E3 ligase TRIM21 to create R-Nb science.org/doi/10.1126/sc…

Why we need a revolution in clinical research. New editorial Brain academic.oup.com/brain/article/… National Institute for Health and Care Research Medical Research Council UK Research and Innovation Wellcome Wes Streeting MP

“..the field is expanding and of course, you need specialists, these domains.. but you need people who can see the bigger picture..” - Prof Kailash Bhatia, MDS youtu.be/gQSKGUic_3U?fe… via YouTube

Excited to share our new work: genetic risk analysis on Chromosome X for Alzheimer’s disease. Implications for risk in men versus women: Chromosome X-wide association study in case-control of pathologically confirmed Alzheimer’s in European population 1/ doi.org/10.1038/s41398…

Great to catch up with Meg Palmer from The PSP Association about past and present research developments.