I wonder if *extremely* dense longitudinal sampling would effectively solve the signal/noise problem for liquid biopsy cancer tests. (Daily+ sampling in a world with ubiquitous ~$1/genome sequencing on devices the size an ONT dongle.) Image credit: Aaron Pomerantz, PhD

Random note: For the language / community with arguably *the most* to gain from codegen, it feels like the opposite is happening. Recently, Posit PBC (formerly RStudio) shipped the beta version of Positron, a fork of VS Code that seems like it will be the future successor to

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/

30 Essays to Make You Love Biology Day 29. "Atoms Are Local," by E. Hershberg Biology is the ultimate distributed manufacturing platform. Cells harvest atoms from their environments—air and soil—and rearrange them to build materials, medicines, and everything we need to live.

I agree with Patrick Malone, MD PhD and would go further to say: Recursion and its clinical read outs - of which there will be more negative results, and surely some positive ones as well (because that's how drug development works) - are just early noise in assessing the

This is absurdly cool. As a professor, drops a solo preprint describing creation of indices for terabytes of metagenomic data, implemented in one Github repo of carefully handcrafted C code with all files at the root level of the repo. The paper is just one 754 line Tex file.

This could be Palo Alto but yall not ready for that conversation.

Currently eating Enzymes (Microbial).