Key point: Events concerning for seizures in infancy can present as PRREs.
doi.org/10.1111/epi.18…

#epilepsy #infant #paroxysmalevents #seizures #EEG #Ilae ILAE @epilepsiajourn Wiley Neuro

Key point: In patients who respond to #CBDO , an increase in Montreal Cognitive Assessment (or MoCA) score was strongly correlated with seizure reduction.
doi.org/10.1111/epi.18…

#epilepsy #cannabidiol #drugresistantepilepsy #EEG #gait #ilae ILAE @epilepsiajourn Wiley Neuro

Key point: In an in vitro slice model, ArcKR expression increased G1-mGluR-LTD, an effect that could be blocked with a mGluR5 antagonist.
doi.org/10.1111/epi.17…

#epilepsy #hippocampus #kainatemodel #depression #mGluR5 #ArcKR #ilae ILAE @epilepsiajourn Wiley Neuro

Key point: Mothers with migrant background and those with low education were more likely to use the most fetotoxic ASMs.
doi.org/10.1111/epi.18…

#epilepsy #Ilae #accesstocare #antiepilepticdrugs #disparities #pregnancy #socioeconomicfactors ILAE @epilepsiajourn Wiley Neuro

Key point: Multidisciplinary care of patients with SCN8A is necessary; resources include early referrals, therapies, and complex care.
doi.org/10.1111/epi.17…

#epilepsy #Ilae #DEE #earlyintervention #SCN8A #phenotypes #severity ILAE @epilepsiajourn Wiley Neuro

Key point: There is consensus on five #SCN8A phenotypes that vary by age at onset, EEG and MRI findings, seizure type, and preferred first-line treatment.
doi.org/10.1111/epi.17…

#Epilepsy #DEE #phenotypes #sodiumchannelblockers #Ilae ILAE @epilepsiajourn Wiley Neuro

Key point: Seizure detection was improved by monitoring focal temperature changes in the epileptogenic zone (sclerotic hippocampus) during #seizures .
doi.org/10.1111/epi.18…

#epilepsy #implantabledevice #neuromodulation #sensors #Ilae ILAE @epilepsiajourn Wiley Neuro

Key point: Electronic health records may be a valuable data source for epidemiological study of rare epilepsies and other rare diseases.
doi.org/10.1111/epi.18…

#epilepsy #ILAE #seizures #Rasmussensyndrome #SturgeWebersyndrome ILAE @epilepsiajourn Wiley Neuro

Key point: Establishing standard electrical stimulation mapping (ESM) testing protocols in children is crucial, which parallels a similar need identified in adults.
doi.org/10.1111/epi.18…

#epilepsy #neuropsychology #SDE #sEEG ILAE @epilepsiajourn Wiley Neuro

Key point: A machine learning pipeline was developed and showed promise for the detection of FBTCS based on data acquired using a connected shirt.
doi.org/10.1111/epi.18…

#epilepsy #machinelearning #seizuredetection #wearablebiosensors #ILAE ILAE @epilepsiajourn Wiley Neuro

Key point: The study findings demonstrate the potential added value of computational biomarkers from #EEG for people with suspected #epilepsy and seizures.
doi.org/10.1111/epi.18…

#biomarker #casecontrol #computational #network #Ilae ILAE @epilepsiajourn Wiley Neuro

Key point: There are significant sex differences in cognitive outcomes post-FSE, where females fare better than males.
doi.org/10.1111/epi.18…

#epilepsy #acetylcholine #febrilestatus #hippocampus #muscarinic #thetagammacoupling #ilae ILAE @epilepsiajourn Wiley Neuro

Key point: 'AAV-Cre-injected mice exhibited a decrease in incidence of posttraumatic seizures following CCI injury, suggesting that mTOR activation in dentate gyrus contributes to epileptogenesis in posttraumatic #epilepsy .'
Epilepsia: doi.org/10.1111/epi.18…

Registration is open for the #ILAE e-Forum: Beyond the seizures in childhood onset #epilepsies , taking place on 10 June 2024! This session features #epilepsy experts Elaine Wirrell, Kette Valente & J. Helen Cross.
Free registration: ilae.org/eforum-1

Key point: Short-term exposure to O3 may reduce the risk of unprovoked seizures, and short-term exposure to NO2 and CO may increase this risk.
doi.org/10.1111/epi.18…

#epilepsy #airpollution #noisepollution #risk #seizures #ilae ILAE @epilepsiajourn Wiley Neuro

How accurate do self-reported seizures need to be for effective medication management in epilepsy?
doi.org/10.1111/epi.18…

#epilepsy #clinical #patientreported #seizures #simulation #ilae ILAE @epilepsiajourn Wiley Neuro

Key point: The ASQ-3 showed good agreement with the researcher-administered Bayley Scales of Infant Development in children of women with #epilepsy .
doi.org/10.1111/epi.18…

#ASM #neurodevelopment #pharmacovigilance #pregnancy #teratology ILAE @epilepsiajourn Wiley Neuro

Key point: New work indicates astrocytic energy demands are higher than previously estimated and impairments in astrocytic Glut1 activity may contribute to disease.
doi.org/10.1111/epi.18…

#epilepsy #acetazolamide #astrocyte #triheptanoin ILAE @epilepsiajourn Wiley Neuro

Key point: AAV-Cre-injected mice had reduced neuronal death and mossy fiber sprouting in dentate gyrus following CCI injury.
doi.org/10.1111/epi.18…

#epilepsy #hippocampus #rapamycin #Raptor #seizure #ILAE ILAE @epilepsiajourn Wiley Neuro

Key point: 'These findings suggest that different seizure outcomes have different underlying biology and risk factors.'
Epilepsia: p0.vresp.com/lHGW0t
#epilepsy #epilepsy research Wiley Neuro