Today we report in Cell a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing.
sciencedirect.com/science/articl…
PDF:drive.google.com/file/d/11959ct…
(1/15)

Out now in Cell!
doi.org/10.1016/j.cell…

Historically marginalized student representation drastically drops from undergrad to grad school.

Are underrepresented students unqualified? Or are grad school admissions unnecessarily confusing, costly, & gatekeeping?

1/🧵

This wouldn’t have been good advice for me because 1. I probably wouldn’t have gone to grad school at all if I got a job after college & 2. Going to grad school (and joining the lab I did in particular) has been one of my best decisions! Depends on the student/field I think

I had the time of my life. Thank you BEYONCÉ! See you next month 👽 #RENAISSANCEWorldTour

I'm thrilled to join Whitehead Institute as a Whitehead Fellow! The Raguram Lab (opening Sept 2023) will study mechanisms of intercellular biomolecule transfer to inform the development of new macromolecular delivery modalities. Stay tuned for more soon! (1/2)

Today we report in Nature Genetics a study led by the team of Jonathan Yen and Mitch Weiss St. Jude that characterizes Cas9 nuclease and adenine base editing strategies to induce fetal hemoglobin expression, clinical approaches to treat sickle-cell disease & beta-thalassemia. 1/10

Good for her for speaking up in the first place, and for not backing down when the moderator tried to quiet her! “When you are accustomed to privilege, equity feels like discrimination.”

Disappointed but not surprised that this Supreme Court continues to upend decades of progress. Lack of racial diversity in higher education will harm us all.

Justice Ketanji Brown Jackson’s dissent in affirmative action is on point.

Excited to share my first paper from my PhD research in Chris Garcia's lab! We determined structures of the IL-21 receptor complex and engineered IL-21 variants that enhanced vaccine responses in tonsil organoids with reduced autoantibody induction. (1/9)
cell.com/cell-reports/f…

Influencer /ˈinflo͝oənsər/ (noun): A person who shares his magic and brings out the very best in others. 🪄

[See also: every person who has ever had the opportunity to work with him]

✨ Happy 50th David R. Liu!!! 🥳 🦄✨

The Little Mermaid movie was heart-warming and a wonderful, fresh take on a classic! Halle is quite the star 🤩🧜🏽‍♀️

🔬 Calling all early-career clinical researchers! 🔬

Are you a postdoc or medical fellow doing clinical research in #RareDisease ? Hit me up! I'm looking for folks willing to share about their research needs in a compensated interview. RTs appreciated! 🙌

#CareAboutRare #ECRchat

It’s fantastic the HSC prime editing field is exploding. Terrific work by Kelcee Everette, Jonathan Yen, David R. Liu and team advancing curative approaches to #sicklecell

Postdoc with Daniel Bauer is off to a great start! Glad to share our News and Views article on therapeutic prime editing for sickle cell disease.
nature.com/articles/s4155…
Here is the original article/thread. Congrats to everyone involved in this collaborative effort!

Goooood morning #ASGCT23 , today’s the day! Stop by poster # 1564 to hear more about prime editing correction of the #sicklecell allele. You can even vote for my poster as your favorite! 👩🏽‍🔬

Hey #ASGCT if you enjoyed hearing David R. Liu talk about therapeutic applications of genome editing technologies pioneered by the lab, you’ll love my poster on the development of a prime editing strategy to correct the #sicklecell allele! Please stop by this Friday! Poster # 1564

Today we report in Nature Biotechnology the development of dual-AAV in vivo delivery systems for prime editors that can support efficient prime editing in multiple organs such as brain, liver, and heart.
1/4

A team led by Kelcee Everette, David R. Liu, Jonathan Yen, and colleagues at Broad & @stjuderesearch shows prime editing can correct mutations causing sickle-cell disease in patient cells, restoring normal blood parameters after transplantation into mice. broad.io/2lp4i7

Thanks so much for the support, everyone! I celebrated with this photo taken by my lovely labmate and a full 8 hours of sleep last night. 👩🏽‍🔬