August 2024 issue is available online. See and download for free the Haematologica Digital Edition! haematologica.org/preview/digita…

#LandmarkPaper_in_Hematology: the paper published in 1970 changed the trajectory of treatment for patients with Hodgkin lymphoma: for the very first time a combination of drugs, in the form of the MOPP scheme, was used successfully. haematologica.org/article/view/1…

New research sheds lights on the leukemogenic mechanism of the ETV6::ACSL6translocation in acute lymphoblastic leukemia through a multi-omics analyses and patient-derived xenograft models. haematologica.org/article/view/h…

A new study analyzes the link between the immunosuppressive effects of D-2-hydroxyglutarate and metabolic reprogramming in dendritic and blast cells in acute myeloid leukemia with IDH1 or IDH2 mutations. haematologica.org/article/view/h…

Ten percent of patients with juvenile myelomonocytic leukemia (JMML) do not harbor a RAS pathway mutation. Read here about seven patients diagnosed with SH2B3-mutated JMML. haematologica.org/article/view/h…

Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative neoplasm affecting children. A new exome sequencing analysis of familial cases of JMML of unknown genetics identified founding variants in the SH2B3 gene, haematologica.org/article/view/h…

Read here results of the IELSG38 trial conducted to investigate the effects of subcutaneous rituximab in front-line treatment with clorambucil and maintenance in patients with extranodal marginal zone lymphoma. haematologica.org/article/view/h…

Mitapivat, a pyruvate kinase activator, is a new hope for millions of patients affected by sickle cell disease (SCD). A comprehensive multi-omics study investigates the impact of mitapivat on red blood cells from SCD patients. haematologica.org/article/view/h…

How is quality of life (QoL) of patients after chimeric antigen receptor (CAR) T-cell therapy? A new review summarizes the most used health-related QoL tools after CAR T-cell therapy and discusses how they may be optimized. haematologica.org/article/view/h…

How to challenge the previously impossible: the concept of achieving cure in multiple myeloma (MM). Find here an overview of the current landscape of MM treatment. haematologica.org/article/view/h…

A Spotlight Review Article on efanesoctocog alfa discusses a highly sophisticated new class of extended half-life factor VIII molecules and a groundbreaking therapeutic agent for inherited hemophilia A. haematologica.org/article/view/h…

Beyond genetics in hemochromatosis: two twins, same gene mutations but different phenotypes. haematologica.org/article/view/h…

When classical meets malignant: a case of acquired εγδβ-thalassemia in clonal hematopoiesis haematologica.org/article/view/h…

September 2024 issue is available online. See and download for free the Haematologica Digital Edition! haematologica.org/preview/digita…

In a detailed case report, Krzysiek et al. documented that complete response to elranatamab, a B-cell maturation antigen-CD3 bispecific T-cell engager, was associated with clonal CD8+ T-cell expansion in refractory multiple myeloma. haematologica.org/article/view/h…

A new predictive model of clinical and genetic factors to prognosticate outcomes after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. haematologica.org/article/view/h…

Allopurinol should be used in maintenance therapy for pediatric acute lymphoblastic leukemia to mitigate hepatic toxicity of 6-mercaptopurine metabolism. Read here results of a prospective phase II study. haematologica.org/article/view/h…

In the era of precision medicine a new study teaches us how to identify children with sickle cell disease who are at risk of developing overt stroke. haematologica.org/article/view/h…

Is immune evasion responsible for dissemination of systemic diffuse large B-cell lymphoma to the central nervous system? Read here results of a comprehensive immunological and molecular profiling of a cohort of patients. haematologica.org/article/view/h…

Despite the widespread implementation of molecular tumor profiling for diagnostics, there is still a debate as to whether tumor-normal sequencing is preferred or deemed unnecessarily costly compared to sequencing of only tumor material. haematologica.org/article/view/h…