Tissue characterization at an enhanced resolution across spatial omics platforms with deep generative model dlvr.it/TBRtXS #MachineLearning #NatureJournal #AI

We developed an imaging-free spatial genomics technology where DNA barcodes diffuse to connect locally. Using UMAP, we reconstructed the physical locations of these barcodes, transforming spatial transcriptomics into purely molecular biology. biorxiv.org/content/10.110…

Also proud to co-post IRISeq alongside two other innovative imaging-free spatial genomic approaches: 1) SCOPE from Sanjay Srivatsan and Jay Shendure lab (biorxiv.org/content/10.110…); 2) Imaging-free spatial genomics from Chen lab Fei Chen Lab (biorxiv.org/content/10.110…).

Bead-bead connection information == Spatial information👍

Life is like the tide, always changing. Embrace the inevitable waves and navigate through them with grace, confidence, and joy😊

Genetics of Chronic Kidney Disease | NEJM nejm.org/doi/full/10.10…

Singleron automated single cell dissociation machine😯

StaVia: spatially and temporally aware cartography with higher-order random walks for cell atlases genomebiology.biomedcentral.com/articles/10.11…

👐🏻👐🏻👐🏻

There's been lots of attention to how GLP-1 drugs have been outperforming expectations in ways not fully anticipated. Such is the case for SGLT-2 inhibitor drugs, too. Potential new effects: —Prostate cancer reduced risk sciencedirect.com/science/articl… —Less kidney scarring, dysfunction

Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics nature.com/articles/s4158…

Nature is amazing! Congratulations to Max Wilkinson and team on a beautiful study revealing a clever way that bacteria defend against viruses. Check out Max’s posts for more detail! doi.org/10.1126/scienc…

Very excited to share our latest study to represent the graph signal on spatial omics data using graph Fourier Transform. 😀 😀 nature.com/articles/s4146…

📣 The much-revised manuscript of LIANA+, our all-in-one solution to study cell-cell communication from single-cell, spatial, and multi-omics technologies, is now published in Nature Cell Biology nature.com/articles/s4155…

Meet Dr. Sheng Chih (Peter) Jin Sheng Chih Jin! His lab is breaking new ground by combining human genetics, functional genomics, and bioinformatics! They've just received R01 funding from the NIH, a major achievement! Congratulations to Dr. Jin's lab! 🎉 👉genetics.wustl.edu/faculty-spotli…

A step-by-step to FixNCut…perfectly compatible with all 10x Genomics applications

Congratulations to Xiao Zhang et al. for this fabulous work! Catecholamine-independent lipolysis in the bone marrow adipose tissue - new knowledge of lipid metabolism👍

The Wild West of spike-in normalization go.nature.com/3XLUMw3

1/16) We are excited to share our recent paper “ADAMTS12 promotes fibrosis by restructuring extracellular matrix to enable activation of injury-responsive fibroblasts” published today @Jclinicalinvest led by Konrad Hoeft and Lars Koch jci.org/articles/view/…

Happy to share our new Nature Reviews Nephrology review: Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease. Led by Veronica Miguel and Isaac Shaw, Free text here: nature.com/articles/s4158…