Frequency of TCFA, micro-channels, macrophages, and intimal thickness was significantly higher in older ACS patients compared to very young patients.
Sarah Moharem Elgamal, MBBCh, MSc, PhD👩🏻‍⚕️🫀
Özge Özden Kayhan EACVI President
Henry Han
Stefano Nistri ⬛️ Julia Grapsa
Edoardo Zancanaro MD
academic.oup.com/ehjimp/article…

How to define #PreHF stage⁉️

Dr #AntoniBayesGenis and BiykemBozkurt proposed 3 categories to define this grey
area:

1️⃣Structural Heart Abnormalities
-🫀structural/functional issue w/o ⬆️ NPs
- e.g: LVH, chambers enlargements, wall motion abnormalities

2️⃣Heart Stress
-⬆️ #Biomarkers

#SYNERGY -NASH Phase II

📌In a 52-week study, #tirzepatide significantly improved #MASH resolution without worsening fibrosis, with 44% (5-mg), 56% (10-mg), and 62% (15-mg) success rates compared to 10% for placebo.

📌 #Fibrosis improvement rates were higher in tirzepatide

GLP1s were associated a gastric emptying delay that was of low and limited clinical significance, in a meta-analysis of 15 randomized trials.

journals.lww.com/ajg/abstract/2…

Loop #diuretic utilisation with or without #HeartFailure : impact on prognosis

📍198,898 patients analyzed (median age 65, 55% women) in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿

📍81% neither took loop diuretics nor had heart failure.

📍12% took loop diuretics without heart failure (5-year mortality: 40%,

Our paper today in JAHA led by Karthik Gonuguntla on Mortality in Premature Myocardial Infarction (PMI)
🫀 Over 2 decades, there has been an ⤴️ in proportionate mortality of PMI in women & Black; higher PMI in Native population
🫀 This despite an overall ⤵️ in AMI mortality

Almost 90% of US adults met criteria for cardiovascular, kidney, and metabolic syndrome (stage 1 or higher) and 15% met criteria for advanced stages, neither of which improved between 2011 and 2020.

ja.ma/3wTJSd4

#Diuretics in pregnancy: Data from the #ESC Registry of #Pregnancy and Cardiac disease ( #ROPAC )

📍Diuretics used in 6.7% (382/5739) of pregnancies

📍Commonly used diuretic: furosemide (86%)

📍Associated factors:
🔹Age >35 (OR 1.5)
🔹Other cardiac meds (OR 5.4)
🔹 #HeartFailure

RCTs typically designed/analyzed as if there is a single homogeneous rx effect, assume effect variability is negligible, “random”. This casts a veil of ignorance over actual underlying heterogeneity, potentially resulting in sub-optimal rx for some. #HerbertWeisberg #MeganHiggs

CV medicines that should either be deprescribed to prevent harm or for a lack of benefit or be switched to better alternatives

When cardiovascular medicines should be discontinued ?

#CVPharmacology #CardioEd
academic.oup.com/eurheartj/adva… Konstantin Krychtiuk European Society of Cardiology European Society of Cardiology Journals

Point-of-care high-sensitivity cardiac troponin in suspected #AMI assessed at baseline and 2 h

This international, multi-centre, prospective, observational studies demonstrates that 2-hour algorithm using hs-cTnI (Siemens Atellica® VTLi) effectively identifies low-risk (NPV:

Join my University of Vermont Team in 2024 Vermont Heart Walk

www2.heart.org/site/TR?team_i…

Was it all that bad? #HF specialised care improves outcomes even throughout the #COVID19 pandemic -data from the #NHFA . See the Patient -> treat the patient -> live longer bit.ly/3VsvOQY

#EJHF HFAPresident Antonio Cannata' Henry Han Djawid Hashemi Marco Metra

How Mediterranean Diets Might Cut Mortality in Women: New Insights dlvr.it/T7tBqG

Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the European Society of Cardiology Working Group on Myocardial Function

onlinelibrary.wiley.com/doi/full/10.10…
#CardioEd #HFA

European Society of Cardiology Journals Wilfried Mullens Gianluigi Savarese Marco Metra European Society of Cardiology News EJHF Editor-in-Chief

Stuart J. Connolly, Clinical Trialist and Arrhythmia Medicine Pioneer, Dies at 75 tctmd.com/news/stuart-j-…

Provide #HF specialist care even during dramatic times
leads to 👆💊 and 👇🪦 for #HF rEF and #HF pEF.

A nationwide analysis from the #NHFA across the #COVID pandemic.

European Society of Cardiology Journals Henry Han Antonio Cannata' Gianluigi Savarese Djawid Hashemi Antonio Jordán

doi.org/10.1002/ejhf.3…

Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant?

'GLP-1-based anti-obesity meds show significant weight loss, but 25-40% is lean body mass, raising concerns about physical function and frailty.

Studies show varied impacts on muscle mass and strength, highlighting

JAMA invites articles for new article series, 'Integrating Clinical Trials and Practice,' that explore innovations in trial design, implementation, funding, regulation, education, & application that bring RCT evidence to address clinical practice needs.

ja.ma/3V65db1