Since the Universe has no center, you can’t be it.

Yes!

My 6 year old nephew wants to be a firefighter who is a scientist in his spare time. Oh and yes, he only wants to discover novel things. I feel exposed now.

Excited to share our recent study in Immunity demonstrating a role for GSDME-mediated pyroptosis in cutaneous antiviral defense. This project began while I was a post-doc with Jonathan Kagan Boston Children's and was completed in my lab @UMassMedical. 1/11 authors.elsevier.com/c/1d2qd3qNrUmR…

First review article from the lab was just accepted! Congratulations to co-author and Orzalli lab graduate student Pooja Parameswaran! Morningside Graduate School of Biomedical Sciences Department of Medicine

Thank you Megan Orzalli for the opportunity to contribute to this review and for introducing me to the fascinating world of guard proteins and effector triggered immunity!

Our August issue is out! hubs.la/Q02JTSw30. The cover shows HSV-1 infection inhibiting ASC speck formation in an A549 cell line. ASC-GFP is in green, ICP0 from HSV-1 is in red, & cell nuclei are in blue. From Pooja Parameswaran Megan Orzalli et al. hubs.la/Q02JTy5C0

.JExpMed's August issue is out! hubs.la/Q02JTKHS0. The cover shows HSV-1 infection inhibiting ASC speck formation in an A549 cell line. ASC-GFP is in green, ICP0 from HSV-1 is in red, & cell nuclei are in blue. From Pooja Parameswaran Megan Orzalli et al. hubs.la/Q02JTzhr0

We've started IND-enabling studies on a small molecule corrector for Rho-associated autosomal dominant retinitis pigmentosa (Rho-adRP). I thought it would be fun to spend some time walking through our approach and why we are excited. Long 🧵1/