A little late to my own party, but I'm excited to share my research that was recently published @nature. Big thank you to the collaborators, mentors, and colleagues who made it possible. Together we answered a long-standing question in cell cycle biology!

Excited to share our review of TCR sequencing technologies out now in Nature Methods! nature.com/articles/s4159…

Awesome opportunity to work with King L Hung on extrachromosomal DNA in cancer!

We're ecstatic to present our manuscript on recording the evolutionary dynamics in a mouse model of lung cancer with an evolving lineage tracer. Congrats to Dian Yang for co-leading and Jonathan Weissman's Lab Yosef Lab Jacks Lab for this joint effort. Biorxiv link: tinyurl.com/f43de4nw

We are looking for postdocs, particularly from traditionally underrepresented backgrounds in STEM, who would like to share their work at our weekly seminar series! If this is of interest to you or someone you know please use our nomination form: forms.gle/F5LBkimjtTJ7qb… 1/3

So grateful for the opportunity to present my PhD work at Stanford Cancer Biology retreat!

Today we release in bioRxiv a method for isolating megabase-sized, oncogenic extrachromosomal DNA from human cancer cells. A collaboration with Howard Chang, Jens Luebeck, Siavash Raeisi Dehkordi, Vineet Bafna, Mischel Lab and others. (1/n) biorxiv.org/content/10.110…

NEW #ResearchHighlight! King L Hung, Katie Yost, Xie Frank Xie lab et al. Howard Chang show that extrachromosomal DNAs (#ecDNAs) are held together in hubs in the nucleus & that their interactions can enhance oncogene expression. @nature 📯 go.nature.com/3e9jijb @natrescancer

Our preprint on divergent clonal differentiation trajectories during T cell exhaustion is now on bioRxiv! We investigate whether all antigen-specific T cell clones follow the same differentiation trajectory during chronic viral infection and find heterogeneous clonal behaviors.

I'm thrilled to share our latest work performing genome-scale Perturb-seq screens to explore a remarkable breadth of questions in genetics and cell biology (thread below). Congrats to Reuben Saunders, Tom Norman, and @JSWlab for co-leading this work. biorxiv.org/content/10.110…

Beautiful work on spatial mapping of T cell clones!

🎉My turn! Super excited to join Keck School of Medicine of USC USC Norris Comprehensive Cancer Center as an Assistant Professor in early 2023. My lab will decode inter-cellular communication and intra-cellular molecular programming to develop precision immune therapeutics. Stay tuned for lab website and hiring! 1/n

So excited to share our work out in Nature Immunology !!! We analyzed antigen-specific CD8 T cells differentiating down effector/memory vs exhaustion (Exh) lineages using scRNAseq/scATACseq. Major findings 👇 E. John Wherry Penn Medicine nature.com/articles/s4159…

Excited to announce the Yang lab officially opens at Columbia University University. We are interested in developing innovative single cell recording technologies to study tumor evolution and cancer plasticity. We are hiring motivated postdocs & students, please RT dianyanglab.com