Misfolded synuclein was detected in CSF in a fraction of former Canadian football players. The presence of misfolded synuclein did not correlate with differences seen in other neurodegenerative proteins. loom.ly/lFW4mI0

DBS is efficacious in reducing motor complications in PD. Drs. Poewe and Mahlknecht discuss the latest evidence on how DBS alters symptoms, disability, and survival in PD. They also contemplate the question: how early can this treatment be used? loom.ly/irN5_Bk

Peripheral blood erythrocytic α-Syn is a new marker previously shown to differentiate PD from controls. Abnormal levels are now also reported in IRBD and merit prospective testing in clinical research contexts as a screening tool for early synucleinopathieshttps://loom.ly/CFcbJR0

Longitudinal findings from the UK biobank show an association between higher intakes of vegetables, nuts, and tea and a lower risk of incident PD. loom.ly/MDv9fso

Lower postmenopausal bone mineral density and osteoporosis associated with PD risk in a large retrospective Korean study of over 200,000 women ages 66 and older. loom.ly/abVMDfc

Dr. Weintraub makes the important case that recent advances in biomarker science, including α-synuclein SAA, have shifted the status quo on whether we should regard PD and DLB as two different diseases or as a unified single condition. loom.ly/DpMwhIo

A retrospective cluster analysis involving two tracer imaging--striatal DaT SPECT and MIBG adrenergic cardiac scintigraphy-proposes the existence of two discrete PD subtypes: “cardio-cortical impairment” (CC) vs. “dopaminergic-dominant dysfunction” (DD). loom.ly/b2gtxYQ

A new X-chromosome–wide association study in a Latin American cohort has identified novel candidate PD risk variants. loom.ly/5YM5XpQ

Dr. Maas provides a critical overview of hard choices related to the selection of outcome measures that face the ataxia field in its attempts to improve ataxia clinical trial design. loom.ly/lVPlhpA

A natural history study of sporadic late-onset cerebellar ataxia without a known family history shows that SCA27B, related to a GAA expansion in the FGF14 gene, had a 12.7% prevalence across the cohort. loom.ly/44tx3oY

The Editor of Movement Disorders Journal is pleased to recognize the top reviewers for their service in 2022. These reviewers each contributed over 7 reviews in 2022, submitting their detailed reviews on time and with valuable comments for the editors and authors.

Congratulations to the authors of the Movement Disorders Journal Review Article of the Year: How Does Deep Brain Stimulation Change the Course of Parkinson's Disease? loom.ly/FxdbiT0

Congratulations to the authors of the Movement Disorders Journal Research Article of the Year: Long-Duration Response to Levodopa, Motor Learning, and Neuroplasticity in Early Parkinson's Disease loom.ly/lPRCyy0

An open label trial of sodium oxybate in alcohol-responsive Essential Tremor of Voice showed widespread voice improvement after treatment along with fMRI BOLD signal changes in cerebellar networks relevant to voice tremor. loom.ly/ZGwEjBc

A statistical modeling exercise of published PD trials shows the limitation of current UPDRS-centered endpoints and quantifies the characteristics of the UPDRS placebo response across trials as well. loom.ly/OPWmf34

Dr. Shaefer provides a thought-provoking overview of conceptual hurdles and methods relevant to training new learners to think about the phenomenological diagnoses of movement disorders. loom.ly/gKrLpR8