A UMED Lodz (Uniwersytet Medyczny w Łodzi) and Gdański Uniwersytet Medyczny (GUMed) team including Dr. Braun provide a summary of the existing both pre- and clinical studies of the role of FGFR4 in #BreastCancer , with a special focus on its contribution to #SubtypeSwitching during metastatic spread.

go.nature.com/3W217Tu

🌍 A new Lancet Commission sets out recommendations to tackle urgent global challenges in breast cancer. Supported by NIHR Research, the Commission reveals that despite significant improvements inequities persist.

bit.ly/3xJDV2o

✨Garvan Institute of Medical Research scientists including Elysse Filipe show that softer tumor microenvironments may be contributing to changes in disease outcome by imprinting on TNBC cells a greater metabolic flexibility and conferring discrete cell survival advantages.

bit.ly/3Jr3sQy

Scientists revealed that the upregulation of #collagen type V alpha 1 in triple-negative breast cancer tissues, particularly in chemoresistant samples, was closely linked to an unfavorable prognosis.

go.nature.com/3W0ZYM4

A recent paper by Case Western University (CWRU School of Medicine) scientists including Chun-Peng Pai and Dr. Hung-Ying Kao challenge the conventional understanding of PML as a tumor suppressor and redefines its role as a promoter of tumor growth in breast cancer.
go.nature.com/3vRqTPN

The glycolytic metabolite methylglyoxal transiently inactivates #BRCA2 function, bypassing Knudson’s “two-hit” requirement 👊👊, linking inks metabolic reprogramming, metabolic disorders, or diet to cancer initiation. | CSI Singapore

bit.ly/3Q36H4q

Using #BreastCancer cell lines and patient-derived 🧫 #organoids , 🥼 researchers from King's College London demonstrate that 💊 Neratinib in combination with Trastuzumab may be effective in a subset of HER2-low breast cancers.

🔎 Learn more in British Journal of Cancer!

go.nature.com/3Q4ZBwa

😎 Check this out in Cancer Cell!

Scientists used a comprehensive approach, including a multi-omics & real-world clinical sequencing cohort, along with patient-derived 🧫 organoids to explore 🧬 genetic interactions in #BreastCancer .

👉 bit.ly/3VVos9g

👀 New this week in Cancer Research!

🥼 A research team 🔎 identified MILIP as an RNA translation elongation factor that promoted protein production in #TNBC cells.

🔗 bit.ly/3PWz4Ry

🥼 Researchers at Texas A&M University and the CU Cancer Center have received a $3.3 million grant from the NIH to study how a pair of molecules that regulate certain types of metastatic #BreastCancer interact with a new 💊 drug therapy.

Learn more here 👉 bit.ly/3TTzYQ2

💡 New in CDD press!

🥼 Investigators highlight the regulation of a functional subtype of #mammary fibroblasts by Sprouty 🧬 genes and their essential role in epithelial morphogenesis and cancer development.

🔎 go.nature.com/4amb2aR

In this 📚 #review , scientists provide insight into the complex landscape of #BreastCancer 💊 treatment and potential pathways for improving patient outcomes through targeted breast cancer #StemCell therapies.

🔎 bit.ly/3xxKHrX

💡 New in Scientific Reports!

A team of 🔬 scientists at Università Roma Tre present new findings identifying MELK and ALK as 🎯 targets for the treatment of ERα-positive #BreastCancer .

😎 Check it out! go.nature.com/3vJQcDk

💡 New in Clinical Cancer Research!

🔬 Researchers at MD Anderson Cancer Center examined the efficacy of IRX4204, a highly specific rexinoid, in #BreastCancer 🧫 cell lines and preclinical models to 🔎 identify a #biomarker for response and potential mechanism of action.

➡️ bit.ly/3xtVinG

A team of 🔬 scientists from Xuzhou Medical University elucidate the potential mechanisms of YY1-mediated #BreastCancer metastasis and the possibility of YY1 as a predictor of cancer 🩸 #metastasis .

👀 Check it out in DMD (ASPET)!

➡️ bit.ly/4aAajmk

A team of scientists, including 🥼 Drs. Senthil Muthuswamy (Senthil K Muthuswamy), Dipikaa Akshinthala, & Mike Oliphant report the development of an #organoid culture 🧫 media for the generation and maintenance of ER+ #BreastCancer organoids.

👀 BreastCancerResearch | bit.ly/3vwd5dr

A research team from University of Nebraska Medical Center explores the role of nuclear phosphoinositide signaling in control of YAP/TAZ activity, and implicate this pathway as a potential therapeutic target in #BreastCancer .

🔎 The EMBO Journal | bit.ly/43MV5bh

🥼 A research team from Centre for Genomic Regulation (CRG) explores the physical, biochemical, and genomic differences between #BreastCancer cells 🧫 cultured in 2D and as 3D #spheroids .

😎 Check it out in The EMBO Journal!

bit.ly/3vAY89T