Mark Leick
@mark_leick
MD | Assistant Professor at HMS | MGH Bone Marrow Transplantation and Cellular Therapy | Maus lab post doc | @OslerHousestaff 2014-2017
ID: 812431460846145536
23-12-2016 22:55:29
28 Tweet
264 Followers
134 Following
Its finally out Nature Medicine ! Excited to share our work identifying an association between CAR-Tregs and relapse/resistance after CAR-T cell treatment in DLBCL via scRNAseq and then modeling it in vivo (along with much more!)
Large propensity score matched study #axicel vs #tisacel in Nature Medicine by Emmanuel Bachy et al Closely matched large cohorts ⬆️ ORR, CR, PFS & OS advantage for #axicel pts 1 yr OS 63.5% vs 48.8% p=0.0072 ⬆️ G1-2 CRS, & all grade ICANS in #axicel pts #CART #lymsm #DLBCL
SPOTLIGHT: Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell #lymphoma Mark Leick Satyen Gohil Gaddy Getz Dr Marcela Maus. Originally published in Nature Medicine. To read our summary click ow.ly/zu6N50KVJTZ and scroll all the way down.
We're excited to share the 1st clinical experience delivering intracranial B7-H3 #CARTcells to treat #DIPG in Cancer Discovery, a journal of the AACR. #1: on behalf of Seattle Children's & Seattle Children's Therapeutics (SCTx), we are humbled by our patients' trust and bravery. (1/2) aacrjournals.org/cancerdiscover…
Thoughtful piece in Nature Medicine from Eddie Cliff, Reid Merryman, Philippe Armand and Caron Jacobson Harvard Medical School Dana-Farber on #CARTcells in #DLBCL. Thanks for writing this! #lymphoma #lymsm
If you assumed we are talking about CAR-T, you would be correct! Jae Park Dr Marcela Maus Mark Leick #ASH22
Great talk on germline HLH variants affecting CAR-T toxicity by Mark Leick Dr Marcela Maus , looking forward to collaborating! #ASH22 Frederick L. Locke
We are hiring! Interested in engineering, genomics and T cell therapies for cancer? Want to work with awesome people? Looking for a great place to live? Come join us in St Louis! More info about us here: sites.wustl.edu/nathansinghlab/ Apply here: wustl.wd1.myworkdayjobs.com/en-US/External… Please RT!
If your ✈️ got cancelled ❄️, if you take one CAR-T review to a deserted island 🏝️, if you want to learn about CAR-Ts and don't know where to start... Louai Labanieh and Crystal Mackall Lab just published an epic review. nature.com/articles/s4158…
Excited to share that Majzner_Lab is moving to Dana-Farber Dana-Farber/Boston Children's as of Sept. Bittersweet to leave Stanford, but looking forward to growing our research program both in the lab and in the clinic. Hiring postdocs, scientists & lab manager- please reach out if interested!
Today, NEJM published our clinical study of a novel #CARTCell in patients with #Glioblastoma. Early results with CARv3-TEAM-E suggest safety and bioactivity. Special thanks to all collaborators MGH Neurosurgery and Mass General Cancer Center! nej.md/3VnjUIq