Happy sharing insights from the lab of Claudio Cantù at the Abcam Helmholtz Munich | @HelmholtzMunich summer school on chromatin biology - great experience!

Our paper on the architecture of the #chikungunya virus replication organelle is out eLife - the journal. Congrats to our PhD student Tim Laurent and all other authors! A 🧵on the main findings. (1/8) #teamtomo #cryoEM elifesciences.org/articles/83042

I'm super excited to have this out - and I'm hopeful it can be as helpful for others doing CUT&RUN analysis as it is for me! Try it and let us know :)

Do you want to know what their secrets are? Limb positional identities in their epigenetic profiling would be the answer. Chromatin states at homeoprotein loci distinguish axolotl limb segments prior to regeneration biorxiv.org/content/10.110…

Our CUT&RUN-LoV-U protocol is now online Development doi.org/10.1242/dev.20… Please use it to map the genome-wide binding pattern of non-DNA binders FYI, it works well also with all types of targets We'd LoV ❤️ to know how this protocol works in your hands - please feedback!

A new CUT&RUN low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/β-catenin tissue-specific genomic targets An #OpenAccess Techniques and Resources Article from Gianluca Zambanini, Claudio Cantù, et al Linköpings universitet journals.biologists.com/dev/article/14…

Two great new methods out today in Nature Biotechnology on multi-target chromatin profiling using nanobody-tethered Tn5 transposases: 1) NTT-seq from Raimondi Ivan and Rahul Satija... nature.com/articles/s4158… 1/3

The Time-Resolved Genomic Impact of #WNT/β-catenin signaling Cell Systems Cell Press cell.com/cell-systems/f… We show -β-catenin repositions over TIME ⏰ -How this impacts global transcription⬆️⬇️ -Preceding and following chromatin dynamics🧬 Efforts driven by Pierfrancesco Pagella