Mykhailiuk Chem πΊπ¦
@mykhailiukchem
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http://www.mykhailiukchem.org 19-08-2020 12:34:12
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We love to increase the repertoire of saturated benzene bioisosteres for medchemists! Today in Angewandte Chemie: bit.ly/3SrPovh
A SUPER FAST one-step synthesis of borylated cyclobutanes on scale! Now, in Chemical Science: rsc.li/49aee8D
The craziest molecule Iβve seen recently: Enamine Ltd πΊπ¦ Mykhailiuk Chem πΊπ¦ βs group chemists push the boundaries of organic synthesis literally every day. Such molecules are known to have strong βWβ-like β΄J(H-H). In this case it is ~9 Hz. #pharma #drugdiscovery #nmrchat
Pauson-Khand reaction with triplet nitrenes instead of CO via relay of triplet reactivity. Synthesis, computations, flow & MedChem. science.org/doi/10.1126/scβ¦ Very excited about this wonderful team effort Fang Li ζζΉ Wenxin Felix Zhu ClaireEmpel @27_03_2022 Mykhailiuk Chem πΊπ¦ Proschak Lab
In 2020, we reported on O-[2.1.1]s (bit.ly/3Iwtt0j), and these cores immediately skyrocketed in medchem. Today, we disclose a full story on their synthesis, characterization, and validation as benzene bioisosteres. Published in Angewandte Chemie : bit.ly/4a49t0C
Rapid functionalization of alkenes by in situ-generated difluoromethyl nitrile oxide. Published in J Org Chem/Org Lett : pubs.acs.org/doi/10.1021/acβ¦
I may not be the biggest fan of 111/BCPs but this new ChemRxiv from Enamine Ltd πΊπ¦ πΊπ¦ and Mykhailiuk Chem πΊπ¦ is excellent! Light activated functionalization but without photocatalyst - scalable too thanks to flow! And the scope...wow!! chemrxiv.org/engage/chemrxiβ¦
Thanks Organic Process Research & Development for highlighting our reagent! Original preprint is here: bit.ly/3W0nWqA
This work is in Nature Synthesis! go.nature.com/3Xum7CO Massive amount of work by Vasyl Ripenko, Vadym Sham, and colleagues at Enamine Ltd πΊπ¦! >300 commercialized BCPs are now open to the world! European Research Council (ERC)