“When we recommend the best treatment for patients on the basis of their individual characteristics, we are applying the concept of heterogeneity of treatment effect.” Read the full editorial by Drs. Christopher J. Yarnell and Michael Fralick: eviden.cc/3TuT2DP

Original Article: Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura (cTTP Phase 3 trial) nej.md/3UEqGc2

#Hematology

Alectinib improved disease-free survival compared with chemotherapy in patients with early stage, resected ALK-positive non–small-cell lung cancer. jwat.ch/4b1ji0q

NEJM Jyoti D Patel

In the final results of a randomized trial involving patients with HIV infection, pitavastatin reduced the incidence of adverse cardiovascular events at 5.6 years of follow-up as compared with placebo. Read the full correspondence: nej.md/3UHT2m1

Dr. Peter Marks, director FDA Biologics, discusses the manufacturing process and potential risks associated with CAR T-cell therapy. Gain a deeper understanding of the complexities surrounding this innovative treatment on Intention to Treat: nej.md/itt-ep29

Morning Report: “A 70-Year-Old Woman with a Sensation of Something Moving in Her Nose” by Marlene M. Speth, MD, MA, et al.: eviden.cc/3IMTx7l

#Otolaryngology #MedTwitter

A 63-year-old woman was noted to have white-yellow rings in both eyes. On slit-lamp examination, two concentric rings were seen in each cornea. Read the full clinical case: nej.md/3Uk5l6p

Cryptococcus accounts for up to 180,000 deaths annually and 68% of HIV-related meningitis cases. The authors of a new review discuss diagnostic, preventive, and therapeutic strategies and the pathophysiological role of inflammatory syndromes. Full review: nej.md/44ni39a

Congenital thrombotic thrombocytopenic purpura results from hereditary deficiency of ADAMTS13. Prophylactic administration of recombinant ADAMTS13 achieved normal blood levels with limited toxicity and no neutralizing antibodies. Full cTTP trial results: nej.md/3UEqGc2

Original Article: Transcatheter or Surgical Treatment of Aortic-Valve Stenosis (DEDICATE-DZHK6) nej.md/3TLx8MT

Editorial: Another Early Win for TAVI in Low-Risk Patients nej.md/3J5F7j5

Original Article: Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction (AEGIS-II) nej.md/3U4yxzk

Editorial: HDL Therapeutics — Time for a Curtain Call or Time to Reconceptualize? nej.md/49ryYIG

Original Article: Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria (Mali Malaria mAb phase 2 trial) nej.md/3Ug6MTr

Editorial: The Quest for Transformative Tools to Eradicate Malaria nej.md/3UhMUiK

During the social tumult of the 1960s and 1970s, NEJM opened its pages to advocates of reform in the profession and society at large, writes Merlin Chowkwanyun, M.P.H., Ph.D. (Merlin Chowkwanyun, PhD, MPH), but it did not completely break with its troubled racial past. nej.md/4b6xkx6

The quantification of urinary potassium excretion is generally the first step in diagnostic testing for hypokalemia. The use of either a 24-hour urine collection or a spot urine sample is preferred over the use of the transtubular potassium gradient. nej.md/4dc6CoQ

Images in Clinical Medicine: Small-Bowel Bleeding nej.md/3JDbZjv

#Surgery #Gastroenterology

Perspective: Beyond Code Status by Louise Aronson, M.D. nej.md/3Jg5lPM