Pre-print alert// Finally! Evidence that fMRI-guided rTMS is clinically superior for improving psychiatric symptoms vs. a scalp-defined active target: medrxiv.org/content/10.110… - Hi-lites below... 1/5

Just out in AJP: rTMS as a Next Step in Antidepressant Nonresponders: A Randomized Comparison With Current Antidepressant Treatment Approaches. TMS was 5.5X more likely to result in remission relative to the next medication step after 2 failed treatments (27 vs 5% remission).

Repeated transcranial magnetic stimulation was more effective than antidepressant therapy for patients with treatment-resistant depression. bit.ly/46Bww2d

The deadline to apply for the Pathways to Neurosciences mentorship and leadership program has been extended! Apply by Saturday, August 10: neuroscience.stanford.edu/programs/train…

The bigger question is why even consider medication for first line when rTMS has a better side effect profile?

Safe to say we can move past the refrain that "there have been no new psychiatric treatments for 50 years". Brain stimulation, i.e. rTMS, has been a massive breakthrough. Few treatments of any kind are 5.5x more effective for patients with more severe forms of illness.

Your PI when you urgently need the recommendation letter

Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with Corey Keller Angelique C Paulk, now out in Nature Communications, finding that TBS can produce plasticity-like changes in just minutes of stim. nature.com/articles/s4146…

New TBS findings w/ iEEG by brilliant Yuhao 'Danny' Huang, MD! TBS → plasticity in minutes; DLPFC stim affects ACC; Connectivity predicts response! 🧠⚡️Opens new avenues for TBS optimization. More w/ TMS-iEEG, 3x TBS & units soon! Thanks Angelique C Paulk & team for collaborating 🙏 Wu Tsai Neurosciences Institute

Woohoo

pubmed.ncbi.nlm.nih.gov/30153752/ We did it.

postandcourier.com/health/tms-bra…

Thank you, Genevieve Jurvetson!

Thanks, Steve Jurvetson!

“He who jumps into the void owes no explanation to those who stand and watch.” — Jean-Luc Godard

businesstimes.com.sg/lifestyle/prev…

[Highlight of this month] O'Sullivan SJ, Buchanan DM, Batail JV, Williams NR. Should rTMS be considered a first-line treatment for major depressive episodes in adults? Clin Neurophysiol. 2024;165:76-87. doi.org/10.1016/j.clin…

Nature research paper: Frontostriatal salience network expansion in individuals in depression go.nature.com/4dNIfNX