👥RCT of 62 T2DM pts randomized to 12months of daily 10 mg dapagliflozin vs placebo (NCT03782259).

Dapagliflozin:
⬇️circulating IL-1B
⬆️increases plasma ketones
no changes in CMR global myocardial strain, ECV, T2map were observed

Read more on 👇 #CardiovascularDiabetology

🎯Elevated lesion-specific pericoronary FAI emerged as an independent predictor of MACE in pts w/T2DM.

🎯Incorporating lesion-specific pericoronary FAI (>-83.5HU)+CACS (≥100) provided incremental predictive value for MACE in T2DM pts.

Read more on 👇 #CardiovascularDiabetology

👥CMR Study of 357 STEMI pts treated w/pPCI:
🎯Fasting SHR was independently associated w/ impaired cardiac function and MVO.

🎯In DM pts, fasting SHR is an independent determinant of presence and extent of MVO.

Read more on👇 #CardiovascularDiabetology
cardiab.biomedcentral.com/articles/10.11…

Aortic valve calcification divided by the area of the aortic annulus measured by #yesCT allows a better prediction of AS severity and outcome Labo Dr Clavel #AHAJournals Jiwon Kim, MD Kaz Negishi@Cardiologist/ Heart Mafia
ahajrnls.org/4bva1hg

Sub-analysis from ISCHEMIA+ISCHEMIA-CKD trials

👥 pts w/ CCS stratified in normoglycemic, prediabetes (HbA1c 40–47 mmol/mol), or diabetes group

🎯T2DM but not prediabetes was associated with significantly ⬆️risk of all-cause death @FU

Read more on👇 #CardiovascularDiabetology

Honored to have been involved in such an amazing session on physiology at #EuroPCR with a distinguished faculty of friends and colleagues EAPCIPresident Emanuele Barbato Professor Vijay Kunadian Carlos Collet MD PhD Gianluca Campo Valeria Paradies Salvatore Brugaletta Damien Collison #FullPhysiology

🎯the role of #CMD in #Takotsubo syndrome
Antonio Landi Andrea Milzi Luca Bergamaschi Anna Giulia Pavon

Results from the EMPRISE study:
🎯Cardiovascular benefits of empagliflozin vs. GLP-1RA agents were ⬆️in pts w/ ASCVD or HF

🎯In pts w/ advanced CKD, empagliflozin was associated with ⬇️risk of progression to ESKD

Read more on 👇 #CardiovascularDiabetology
cardiab.biomedcentral.com/articles/10.11…

Understanding role of ketones in AMI pathophysiology:

🎯Post-hoc analysis of the EMMY Trial:

🔄3-βOHB levels post-AMI were associated w/ functional and structural cardiac markers at FU.
📈Significant impact of SGLT2i on 3-βOHB levels
Read more on 👇 #CardiovascularDiabetology

🔊 #CardiovascularDiabetology is calling for papers on perivascular adipose tissue (PVAT)

🎯Aim: to highlight the involvement of PVAT in cardiovascular disease and its translational potential as innovative therapeutic target

By Dr. C. Sena (Portugal)
Submission: Open until 01/25

🧐Dyslipidemia is independently associated w/ subclinical LV diastolic dysfunction in obesity:
💥Central fat distribution (android)➡️negative association
💥Peripheral fat distribution (gynoid)➡️positive association

Read more on👇 #CardiovascularDiabetology
cardiab.biomedcentral.com/articles/10.11…

atherosclerosis-journal.com/article/S0021-…

Just published on Atherosclerosis!

EAT quantified from standard CMR cine images using AI can predict MACE in patients undergoing stress CMR
and has an incremental prognostic role beyond standard clinical and imaging parameters!

Gianluca Pontone
Monzino Cardiovascular Imaging Department

📄 Read about combined cardiac damage staging in patients with clinically significant aortic stenosis 👉 onlinecjc.ca/article/S0828-… #CJC

#JACCIMG presents novel intraprocedural 3D ICE navigation for #tricuspid transcatheter edge-to-edge repair. bit.ly/3xyGIvg

#TEER #cvVHD #EchoFirst #cvImaging Nadira Hamid

About uncommon risk factors➡️close association between the oral gut microbiota and diabetic coronary heart disease (DCHD).

Manipulation of the oral-gut microbiome as a potential approach to diabetic CAD prevention?
Read more on👇 #CardiovascularDiabetology
cardiab.biomedcentral.com/articles/10.11…

🔥In AS pts the combined cardiac damage staging, derived from TTE+RHC, was more accurate in predicting mortality than TTE alone.

🎯In a subset of AS pts, the integration of RHC may improve prognostic stratification👇

onlinecjc.ca/article/S0828-…

#CardioX #Cardiology CJC Journals

🩸📈Poor glycemic control is associated with ⬆️ coronary artery inflammation in T2DM pts, as indicated by pericoronary adipose tissue (PCAT) attenuation on CCTA, leading to ⬆️ cardiovascular risk.

Read more on👇 #CardiovascularDiabetology 🫀
cardiab.biomedcentral.com/articles/10.11…
BMC

Epigenetic memories affect trained #immunity and vascular #inflammation in #diabetes . Check our latest work in collaboration with C. C. Monzino and Prof Sam El-Osta Paneni Lab CTEC - Zurich University Heart Center #CardiovascularDiabetology
cardiab.biomedcentral.com/articles/10.11…

🎯Tirzepatide (TZT) positively modulates cardiomyocyte death, fibrosis, and hypertrophy in presence of high glucose concentrations, confirming its potential therapeutic option for HF management RCT!

Read more on👇 #CardiovascularDiabetology
BMC cardiab.biomedcentral.com/articles/10.11…