Whoo hooo!! Congrats to Shicheng and members of Bryan Roth and Brian Shoichet labs for an amazing and thorough interrogation of the structure, function and pharmacology of 5-HT5A receptors! nature.com/articles/s4159…

Congrats!@ImmunologyTang

nature.com/articles/s4158…

😸 nature.com/articles/s4159…

Structural Genomics of the Human Dopamine Receptor System biorxiv.org/cgi/content/sh… #bioRxiv

Excited to share our new paper, out today in nature! We showed that a PVC (basically a 100nm molecular syringe) can be re-wired to deliver proteins into human cells. Thanks to my advisor, Feng Zhang, and my amazing co-authors at the Broad Institute nature.com/articles/s4158…

Merging art with AI. Using the new Outpainting capability,DALL-E 2 imagined how the landscape could look like between famous impressionist paintings from Van Gogh, Monet, Munch and Hokusai [source, read more: buff.ly/3F65vrL]

How do LINE family retrotransposons jump around? Can we reprogram retrotransposons? What does this have to do with Rum and Raisin? Answers here and below!

Finally--structures of D1, D2, D3, D4 and D5-dopamine receptors!! Congrats to folks from Bryan Roth , Eric Xu's lab and many others. nature.com/articles/s4142…

Broad researchers uncover new system in animals that can edit the human genome and may one day be developed into powerful new technology for genome editing. broad.io/Fanzors-news

Thrilled to share my first postdoc paper in ⁦nature⁩! We present a new RNA-guided system, Fanzor. Heartfelt thanks to ⁦Feng Zhang⁩ , Makoto, & team ⁦Broad Institute⁩, and cryo-EM facilities ⁦NYU Langone Health⁩ and ⁦MIT.nano⁩. nature.com/articles/s4158…

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

Excited to announce the opening of the Strecker lab at MGH Molecular Biology/CCIB and HMS Genetics. I am tremendously grateful to all of my labmates who have helped me over the years, my past mentors Daniel Durocher and Feng Zhang, and my new colleagues Dept. of Molecular Biology, MGH for the opportunity!

Now online! Flexible scaffold-based cheminformatics approach for polypharmacological drug design dlvr.it/T4lzYw

Excited to share that our latest work on Fanzor is now online in Cell ! By analyzing structures from different species, we’ve uncovered the structural diversity and how they cut DNA. Huge thanks to Feng Feng Zhang , Makoto, and all collaborators! cell.com/cell/fulltext/…