Dear colleagues, dear members of Life Sciences Switzerland (LS2) #IonChannels & #MembraneTransporters section, the 1st Worldwide Sodium Channel Conference 2024 is coming to #Grindelwald, #Switzerland! Here to register: sodiumchannelseminars.org/Sodium-Channel…

I was often asked what I was working on in Cristina Paulino group. Well, here it is! 🥁🥳 What a fascinating combination of ion channel and secondary active transporter domains in one protein! Great teamwork with Martin Peter Jan Rheinberger nature.com/articles/s4158…

1/10 With great pride I present our newest #CryoEM work pub. in nature. The 1st reported secondary-active transporter directly activated by membrane voltage. Full credit to the amazing Valeria Kalienkova 🇺🇦🌻, Martin Peter & Jan Rheinberger 🧵👇🏽 for more info nature.com/articles/s4158…

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines | bioRxiv biorxiv.org/content/10.110… #CryoEM #transporter #MembraneProteins

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter | eLife doi.org/10.7554/eLife.… #CryoEM #transporter #MembraneProteins

Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP | eLife doi.org/10.7554/eLife.… #CryoEM #antiporter #MembraneProteins

Our work on the human neuronal vesicular monoamine transporter VMAT2 in online nature. This work was led by talented scientists Shabareesh Pidathala and Yaxin Dai Y. Dai, in a wonderful collaboration with Zhe Zhang's lab. nature.com/articles/s4158…

Structural investigation of human cystine/glutamate antiporter system xc− (Sxc−) using homology modeling and molecular dynamics frontiersin.org/articles/10.33…

Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity | Cell Research doi.org/10.1038/s41422… #CryoEM #MembraneProteins

new release1 SpSLC9C1 in lipid nanodiscs apo 8PCZ: dimer 8PD2,3,5,7: protomer state 1-4 w/ cAMP 8PD8: dimer 8PD9: protomer state 1 w/ cGMP 8PDU: dimer 8PDV: protomer "Structures of a sperm-specific solute carrier gated by voltage and cAMP" Paulino lab. Nature.

New preprint from the lab and guess what, it is not about a membrane transporter😱: "Sensory kinase KdpD is a tandem serine histidine kinase controlling K+ pump KdpFABC on the translational and post-transcriptional level". A short thread... 1/4 biorxiv.org/content/10.110…

Cryo-EM structure of TMEM63C suggests it functions as a monomer | Nature Comm disq.us/t/4k6wope #CryoEM #MembraneProteins

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP | Nature Comm disq.us/t/4k7ovfm #CryoEM #ABCtransporter #MembraneProteins

Mimicking the regulatory state of a major facilitator superfamily sugar transporter | eLife doi.org/10.7554/eLife.… #CryoEM #MFStransporter #MembraneProteins

A massive RESOLUTE - Research Empowerment on Solute Carriers collaboration with Centre for Medicines Discovery, #nuvisan, Department of Biochemistry at Oxford University, CeMM, Bayer AG, University of Zurich Work of many many talented colleagues including Syma Khalid, Katharina L. Duerr, Dheeraj Prakaash, Benedikt Kessler, Alvaro Ingles, Giulio Superti-Furga and numerous others

Many SLC superfamily #transporters could be included on this schematic, including organellar Na+/H+ exchangers SLC9A9 and SLC9A6.

Structural basis of anticancer drug recognition and amino acid transport by LAT1 | bioRxiv biorxiv.org/content/10.110…

Uncoupled substrate binding underlies the evolutionary switch between Na+ and H+-coupled prokaryotic aspartate transporters | bioRxiv biorxiv.org/content/10.110…

📢Dear followers! It has been an absolute pleasure to share news on Solute Carriers #SLCs transporters with you during the last 5 years! The RESOLUTE Innovative Health Initiative project is ending soon, but all our resources and datasets are available at re-solute.eu. #CarryTheTorch!

Check out this tour-de-force in technology and assay development by our partners at Novartis, Max Planck Institute for Medical Research, and CeMM: dlvr.it/T7Vyjf