The new mass spectrometry core will provide Mayo Clinic translational and discovery scientists access to MS at single cell sensitivity to aid in the discovery of new therapeutic targets and biomarkers. Am Soc for Mass Spec Human Proteome US HUPO

The newly established Multi-Omics Mass Spectrometry Core at the Mayo Clinic in Florida seeks candidates for a Proteomics Mass Spectrometry Specialist at the level of Research Scientist. jobs.mayoclinic.org/job/jacksonvil…

Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD biorxiv.org/content/10.110…

So excited to share this! We discuss the role of nuclear-import receptors in controlling and chaperoning phase transitions associated with ALS & FTD. Great collaboration between the Rossoll Lab & ShorterLab!
Molecular Neurodegeneration The ALS Association Penn Medicine Mayo Clinic Neuro

Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD, it was great to write this review for Molecular Neurodegeneration with Bilal Khalil Miriam Linsenmeier Courtney L Smith & Rossoll Lab! …arneurodegeneration.biomedcentral.com/articles/10.11…

The latest publication as part of our 'ALS: Challenges and New Advances' review series!

Find all the exciting reviews in this series here: bit.ly/3WHZ2dC

'Nuclear-import receptors as gatekeepers of pathological phase transitions in #ALS / #FTD '

Bilal Khalil Miriam Linsenmeier Courtney L Smith ShorterLab Rossoll Lab Mayo Clinic Neuro Penn Medicine #TDP43

bit.ly/3vMq22t

Happening this Thursday! Don't forget to register! bit.ly/3TS2W4a

🚨📝New review alert! Molecular Neurodegeneration
Great collaborative effort between @Rossolllab and ShorterLab! #Importins #RBPs #PhaseTransition #ALS #FTD

A surprise from the lab now out in nature. The excellent Stephan Tetter set out to determine the #cryoEM structures of #FUS amyloid filaments in frontotemporal #dementia . Instead, he found abundant filaments of its homologue, TAF15!

nature.com/articles/s4158…

Congrats to my remarkable labmate, M.A Ly, on her poster award at ABRCMS! You represent the Rossoll Lab so well!

Thank you for your awesome science and thank you for celebrating life’s achievements with us in a way that was welcoming to all: cocktail & flip flops 💃🏼🩴🥳🧠🔬! Congrats Professor Prof. Melissa E. Murray 📸🔬 !!!!!

TDP-43 nuclear pathology occurs early, prior to cytoplasmic aggregation & preceding symptom onset, suggesting cytoplasmic gain of toxic function & not nuclear loss-of-function, is the primary molecular correlate of clinical manifestation in #ALS #MND 🧵3/4 biorxiv.org/content/10.110…

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS biorxiv.org/content/10.110…

Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the Exceptional imrpress.com/journal/FBL/28…

Wondering about the spatial #proteome of individual cells along gradients? We are releasing scDVP, single-cell #DeepVisualProteomics in intact tissue-context for the first time! Congrats Florian Rosenberger (né Schober) and all!
mpg.pulse.ly/rrq0tf9pa0
nature.pulse.ly/13a4oy6x1y

Our journey of multiplexed DIA, encompassing applications in spatial #singlecell #proteomics , is showcased on the cover of the latest issue of Mol Syst Biol. We are excited about the prospects of sensitivity, reproducibility and high-throughput applications in clinical proteomics.

Just hours before the start of the 1st Conference on “TDP-43 function and dysfunction in disease” in beautiful Trieste, Italy. ⁦ICGEB Official⁩. Can’t wait to see everyone!

Fantastic time Brett Phinney ! Thanks Brett for an amazing course on proteomics. Learned a lot from sample preparation to data analysis! Big shoutout to Rossoll Lab for the sponsorship. Can’t wait to dive into my proximity proteomics data back in Florida!🤩