Reconstitution of bidirectional #mRNA motility with the help of kinesins and #microtubule dynamics! pnas.org/doi/10.1073/pn… Movie: KIF5A (magenta) drags APC-RNPs (cyan) along microtubules. Thanks to Sebastian Baumann, Julia Grawenhoff, Elsa Rodrigues&the lab!

The perfect day for starting a new position #RNA day . I am really excited to announce that today is my first day as #research group leader MPI for Biology of Ageing to work on RNA-binding proteins, #metabolism and #ageing . Can’t wait to fill my lab with #RNA enthusiasts. #recruiting

APC couples several #mRNAs to different #kinesin motor proteins, EB1 & shrinking #microtubule ends which enables bidirectional mRNA motility on dynamic microtubules (mRNA=yellow,EB1=cyan). Thanks to Sebastian Baumann, Julia Grawenhoff, Elsa Rodrigues&the lab! biorxiv.org/content/10.110…

This is one of my last contributions to the RNA transport and in vitro reconstitution fields. I hope this helps others in the future to build crazy transport complexes and analyse their awesome single molecule TIRF data. Special thanks to Julia for here amazing contribution!

Great work by Julia Grawenhoff and Sebastian Baumann passing on our knowledge on how to build and analyze mammalian, cytoplasmic #mRNA transport complexes: link.springer.com/protocol/10.10… #kinesin #microtubules

Finally someone’s getting the truth out about neuronal mRNA transport machineries;) If you are curious check out this very well researched review article by my colleagues Elsa Rodrigues and Julia Grawenhoff

We're excited to describe our research on how gene products are distributed in skeletal muscle! We began these studies with the goal of identifying distinct mRNA localization patterns in muscle, anticipating that mRNAs encoding sarcomeric genes might be locally translated

I am super happy and thrilled that Norges forskningsråd funded my FRIPRO research grant on macropinosome formation. I will be looking for postdocs soon - if you are interested in membrane dynamics and want to play with cool microscopes, get in touch! Centre for Cancer Cell Reprogramming ous-research

I've never been a fan of GFP tags in my reconstitution assays, but when looking at these beauties I might have to reconsider - full length APC-GFP transported by Kinesin on paclitaxel-stabilised microtubules - full frames (512 x 512 pixels) recorded with Surrey Lab TIRF-M

Little animation I was working on last few days 💊
I made this on blender and planning some additional after effects. I'm getting so excited about these new challenges in my journey as a scientific artist #sciart

12 #MotorsInQuarantine sessions wrapped up, 24 great talks, 24 great Q&A sessions, thanks to all speakers, all attendees, my fabulous co-hosts Alex Zwetsloot, Huong, Paula Esquivias, Youchao Chen, and J Cell Science for sponsorship. See you back in September! mechanochemistry.org/whatson/MiQ/

My latest postdoc work finally posted on Biorxiv.

Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression. biorxiv.org/content/10.110…

Really nice talks and beautiful images from Jia Wang NIH and Sebastian Baumann @CRGenomicain on our 10th #MotorsInQuarantine today! Looking forward to seeing you all next week!

📢Join theNiessingLabs! We are looking for a motivated postdoc in the field of #Biochemistry and #HighThroughputScreening 💊🧬

Closing date: 31th of July

Learn more about the research topic and apply here ➡️ biturl.top/6RvUV3

#postdoc #hiring #RNA

It will be our 10th #MotorsInQuarantine this week! We will hear from Jia Wang NIH and Sebastian Baumann Centre for Genomic Regulation (CRG) about myosin in cell-cell contact formation and kinesin in mRNA transport. See you on Wednesday!

So one of the perks of this lockdown was getting around of finally making a designated lab website. Many thanks to my technician Martin Dodel, who is now also a professional web designer! Check it out: mardakhehlab.info

We wrote a review about microtubules in glia!

It's about microtubules in oligodendrocytes (of course), but also astrocytes and microglia (much fewer papers). Also covers disease links.

onlinelibrary.wiley.com/doi/abs/10.100…

We are proud to #announce that we have put together an easy-to-use platform to help you identify whether your favourite #protein has been previously detected as an #RBP or might even be relevant for #COVID19 . Please #retweet and give us your feedback: rbpbase.shiny.embl.de #RNA

I created a portfolio where you can check my Scientific and Nature Inspired illustrations. My hobby is doodling science and nature. I'm also learning new techniques to improve my Protein Visualization skills #PortfolioDay Feedback is appreciated 🍄🎨🙏
leonoramartinez.com

TANGO1 membrane helices create a lipid diffusion barrier at curved membranes biorxiv.org/content/10.110…