The Colonna Lab
@thecolonnalab
We study innate immunity with a focus on ILCs, macrophages, and pDCs. The account is led by trainees.
@wusm_pathology @WUSTLmed
ID: 1387204703969325056
http://sites.wustl.edu/colonnalab 28-04-2021 00:40:55
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Excited to share our new paper in Nature Immunology on how TREM2+ monocyte-derived macrophages in lung cancer reduce activity of natural killer cells that fight tumors. We provide potential dual targeting strategies to improve antitumor immunity. Read here: rdcu.be/damS8
A fantastic talk by our newest MD/PhD graduate Vincent Peng Vincent Peng at #KSinnateimmune23 #KSMyeloid23 on ILCs in mucosal immunity Keystone Symposia
Congrats to Martina Martina Molgora on winning the Research Scholar Award and Stewart Siyan Cao "Stewart", MD PhD on winning the fellowship-to-faculty transition award from the AGA!
Exciting talk from The Colonna Lab on new therapeutic approaches targeting microglia receptors in AD #NIM2023
Congratulations to our former MSTP student, Vincent Peng , on his publication in JEM: "Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway" doi.org/10.1084/jem.20…
Excited to share our latest review describing Group 1 ILCs: Heterogeneity, plasticity, and transcriptional regulation The Colonna Lab - Immunological Reviews - Wiley Online Library onlinelibrary.wiley.com/doi/full/10.11…
Congrats to Jinchao Hou (JinChao Hou) and Yun Chen. Our new study highlights the role of LILRB4 inhibition in enhancing microglial function and reducing amyloid-β accumulation, suggesting LILRB4 as a potential treatment target for AD. science.org/doi/epdf/10.11…
Thrilled to share our work has been highlighted by Dr Monica M. Bertagolli Dr. Monica M. Bertagnolli The Colonna Lab
Excited to share our latest paper: combining anti–PD1 treatment with TREM2 deficiency in mice triggers a proinflammatory response in the gut, promoting the expansion of Ruminococcus gnavus. Congrats to first authors Blanda Di Luccia Martina Molgora Darya Khantakova doi.org/10.1126/sciimm…
Happy to share our new study showing IL-22BP deficiency enhances gut microbiota's defense against infections. This boosts acetate production by Il22ra2–/–associated microbiota, suggesting IL-22BP as a therapeutic target. Led by José Fachi, PhD and Blanda Di Luccia pnas.org/doi/10.1073/pn…
Congrats Patrick Rodrigues! Distinct lineages contribute to cDC2 diversity: lymphoid-derived pDC-like and myeloid-derived pre-cDC2 both develop into transcriptionally similar cDC2, crucial for humoral immune responses, and are distinct from pro-DC3 derived DC3. twtr.to/Tr5-h
Collaboration with The Colonna Lab & others, in press at Developmental Cell: The FGFR1OP gene, implicated in #Crohns, contributes to intestinal barrier function by modulating the actin cytoskeleton in crypt cells. (1/2) cell.com/developmental-…
Our new paper led by Tihana Trsan, collaboration with Xavier Lab, investigating the link between FGFR1OP and Crohn’s disease. Deletion of FGFR1OP, a centrosomal protein, in mouse gut cells disrupts crypt architecture, causing inflammation and fatality cell.com/developmental-…
Check out our newest resource led by Natalia Jaeger and Alina Ulezko Antonova describing the NK-ILC1 gradient in human tissues: rdcu.be/dM64F. The IEL contains true mature (PRDM1+) and immature (PRDM1-) EOMES-ILC1, while other tissues harbor ILC1-like NKs expressing ZNF683.
🧵 Excited to share my first preprint from my PhD Kipnis Lab and The Colonna Lab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Identities from Microglia." 🧠🦴 biorxiv.org/content/10.110…
