Great 2 days of talks at the #AstburyRetreat with #accidentallywesanderson scenes in Buxton

German Rail - No Need to Fly – Around the World in Germany youtu.be/uGtJqnatRbA . Well played Deutsche Bahn

First #cryoEM meeting of the academic year and so many new faces! Absolutely loved everyone's presentations and fun facts, what a creative, talented, crazy bunch of lovely new users we have 😁Thanks to Samuel Haysom for organising! Looking forward the the year ahead!

Presenting our #sustainability website at the end of Code First Girls Level 1 course University of Leeds . Looking forward to Level 2 #python #girlswhocode

Day 1 #WFH = build a desk

Easier (albeit smaller) than expected... Let's gooooo

Who woodn't want one of these? vrlps.co/jNL17tn/tw #plantchange #woodendebitcard

Without a doubt, my favourite author of 2020 Benjamin Lane

Looking forward to hearing more about scientific approaches to tackling climate change this evening at Be Curious LATES. You can sign up here: …escientificsolutions.eventbrite.co.uk UoL Public Engagement #BeCurious21

The last talk of the morning session is by Francesca Chandler talking about her PhD work on ubiquitin signalling #astburyretreat

More fabulous 'atypical signaling' talks at #ASBMB2022. Thanks to all speakers, including Jin Zhang Lab Julia C. Hardy Francesca Chandler

Researchers from across the Faculty of Biological Sciences came together at an away day to share knowledge about their common research interests in drug discovery. Find out more 👇biologicalsciences.leeds.ac.uk/biological-sci…

Delighted to share our latest preprint where we describe first-in-class DUB #MolecularGlues by Francesca Chandler et al. Another amazing collaboration with Roger Greenberg Professor Francesco Del Galdo and Jo Salvino labs. biorxiv.org/content/10.110…

We screened for DUB inhibitors and identified a hit which did not reproduce -- this turned out to be a 'dirty' well in the library. Instead of dismissing it, we characterised it fully and discovered 1) was a highly selective inhibitor for JAMM-domain DUBs and 2) a molecular glue

Amazing efforts from the first author Francesca Chandler showed the mode of action by #cryoEM where 2 small molecules glue a 16-subunit protein complex. Animation credit Jeroen Claus Phospho

Francesca Chandler Jeroen Claus Phospho In collaboration with Roger Greenberg and Professor Francesco Del Galdo teams we showed molecular glues inhibit interferon signalling in cells. A tour de force effort funded by Wellcome and others, and enabled by our amazing research facilities. The Astbury Centre The Wistar Institute Penn Medicine