#Bionano announces a new publication using #OGM to investigate chromosome instability during culture of iPSCs. The paper outlines support for use of OGM in regenerative medicine which could have utility for pharma research and drug development. Read more: bit.ly/3z1zf4K

Our crazy journey on this continues - New Hanna lab Cell paper is out: "Post-Gastrulation Synthetic Embryos Generated Ex Utero Solely from Mouse Naïve ESCs" by the amazing @TaraziShadi Alejandro Aguilera Castrejon @carinejoubran Noa Novershtern & Itay Maza cell.com/cell/fulltext/…

Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys embopress.org/doi/full/10.15…

The International Symposium “Totipotency and Germ Cell Development”

Variable RNA sampling biases mediate concordance of single-cell and nucleus sequencing across cell types biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

We are looking for a senior manager to help lead the Biomedical Data Science Initiative at the U. of U Health Sciences campus. Please share! jobrxiv.org/job/university…

Stem Cell Lines Riddled With Undetected Mutations the-scientist.com/news-opinion/s…

Really pleased this is now online: Inside the race to make human sex cells in the lab technologyreview.com/2022/08/23/105…

Research labs are unable to recruit postdocs. I think alternative options became just so much more attractive. nature.com/articles/d4158…

The HFEA is considering changes, including to the Day 14 rule, to make it “future proof”. More from my The Crick colleague Robin Lovell-Badge here: theguardian.com/science/2022/a…

A summary of current views on epigenetic clocks and rejuvenation. #longevity #aging neo.life/2022/09/2-minu…

Check out the special issue on human embryo development that Dr Naomi Moris and myself put together. Really great reviews! Thanks a lot to all the authors that contributed. sciencedirect.com/journal/semina…

1/ There are too many unanswered questions about women’s reproductive health. ❓Why does menopause occur? ❓What causes endometriosis and can we cure it? ❓What’s the impact of oral contraceptives on mental health? To help find answers Fifty Years is launching reprogrants!

In the latest issue! A transcription factor atlas of directed differentiation dlvr.it/SgfhW6

Postdoc position available to work on human placenta development. We will use live-imaging and transcriptomics in embryos, stem cells and organoids to study molecular mechanisms of development. Please contact me with questions. #reprorocks #reprotwitter jobs.kcl.ac.uk/gb/en/job/0613…

Big news: the "3-parent baby" tech is meant to prevent disease in babies. But new evidence suggests that it might not work in around 1 in 5 cases. Some scientists believe there's a 20% risk of potentially creating a baby with disease. technologyreview.com/2023/03/02/106…

My favorite T2T/Pangenome discovery so far: a multi-megabase inverted segmental duplication on the short arm of chr14 that explains the mechanism of Robertsonian translocations. Great writeup by Stowers Institute "Answering a 50-year-old mystery" stowers.org/news/investiga…

Jumping juniper talk about big #AAV #GeneTherapy news on a Friday! Court invalidated REGENXBIO's claims against Sarepta Therapeutics saying AAV9 patent is invalid b/c it's based on DNA sequences found in nature! Huge implications for all naturally occurring capsid IP!

Complete sequencing of ape genomes biorxiv.org/cgi/content/sh… #biorxiv_genomic

30 Essays to Make You Love Biology Day 1. "I should have loved biology" by James Somers. "It was only in college, when I read Douglas Hofstadter’s Gödel, Escher, Bach, that I came to understand cells as recursively self-modifying programs."