Antimicrobial resistance is a major emerging global threat, and novel drug combinations are a promising approach for countering it. In a new study, EMBL scientists have profiled 10,000+ drug combinations for their effect on key gram-positive bacteria. nature.com/articles/s4156…

How do #antimicrobialPeptides (AMPs) work? 💊 High-resolution cryo-ET images in Nature Communications show AMP pepD2M disrupts the E. coli membrane using a detergent-like mechanism🧼 nature.com/articles/s4146…

Makers of new antibiotics are going out of business before their drugs make it to patients. “Every one of them is an unhappy story.” wsj.com/tech/biotech/a… via The Wall Street Journal

Scoop: Republicans are quietly delaying more than $1 billion in planned funding for PEPFAR — the life-saving HIV program — demanding changes to terms like abortion, sexual reproductive health, even "human rights" in PEPFAR documents. More at The Post: washingtonpost.com/health/2023/10…

In mBio, researchers explore how components of the gram-negative cell envelope prevent compound accumulation, and the efforts to overcome this barrier to inform development of new broad-spectrum antibiotics. Check out the study here: asm.social/1xM

Our new paper, now under review, is on bioRxiv! For the 1st time in the Neuro-infections field, with our meningitis mouse model and 3D whole brain imaging, we elucidated the brain invasion pattern of the #pneumococcus. #IovinoLab Karolinska Institutet biorxiv.org/content/10.110…

Nature research paper: Single-molecule dynamics show a transient lipopolysaccharide transport bridge go.nature.com/3FP2KKT

Antibiotic adjuvants are used alongside antibiotics to minimize or block bacterial resistance. How can they help preserve activity of existing drugs amidst the rising threat of antimicrobial resistance? asm.social/1Ai #WAAW #USAAW23

New work shows that protein ApmA confers broad-spectrum #aminoglycoside #resistance with a molecular mechanism that diverges from canonical aminoglycoside acetyltransferases 🧩💊⤵️ Gerry Wright nature.com/articles/s4158…

An antibiotic from an uncultured bacterium binds to an immutable target... sciencedirect.com/science/articl…

Chicago's first major snow is here! Isn't our campus so pretty?

It's great to see these fantastic pathogens get the attention they deserve. Despite their importance, less than 4 million USD went into Histo research in 2022. Coccidioidomycosis and Histoplasmosis in Immunocompetent Persons | NEJM nejm.org/doi/full/10.10…

Excellent presentations by Loyola MD/PhD Program students Adam S. Bronson & Mai Nguyen at tonight's monthly meeting! Adam presented his research project with the Ulijasz Lab and Mai spoke about residency applications with a focus on PSTP programs. Awesome job by both!

An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance | Science science.org/doi/10.1126/sc…

Congrats everyone! So proud of you.

Multiple papules on trunk & extremities of adult. Diagnosis? More pics: kikoxp.com/posts/17926 Answer: youtu.be/Q88yDU-Pyis?si… #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter

Why are infants susceptible to invasive pneumococcal diseases? Excited to share our latest work led by Kristen Lokken-Toyli which explores this question and elucidates the age-dependent mechanisms that drive pneumococcal spread from the mucosa. PLOS Pathogens journals.plos.org/plospathogens/…

We had a fantastic time celebrating our program and newly minted MD/PhDs (Jesus, Emily, and Mai) at our annual end of year celebration! We have a fantastic, tight knit, group of students here at Loyola! #DoubleDocs

I love that this paper gives us an objective measure of the success rate for phage therapy in these tough-to-treat salvage cases (61% eradication). Congrats to Jean-Paul Pirnay and team on this outstanding work. doi.org/10.1038/s41564…

Check out this new work from myself and the dream team of Jason Zhu, Cullen Lilley, MD, MS, MA, MB(ASCP), Genevieve Crane, MD, PhD, and Kamran Mirza MD PhD - کامران مرزا. It took a ton of time, but I think we've put out an AWESOME product for students, residents, and fellows. Take a look!