Typo-gate!

What a day.... "Too arrogant for its own good" $ALNY vs. "we'll talk shit about our rival but not publicly" $BBIO The ATTR-CM marketing battle will be fun. Enjoy the long weekend, everyone. It's back to (biotech) school on Tuesday, as we race towards the end of the year.

Watch the video. $ALNY CEO Yvonne Greenstreet tacitly acknowledges the 13% ACM RRR at 30 months -- calculation done independently by discussant Sarah Cuddy based on the data made available was correct. There was no error. What Greenstreet tells Amy Brown -- correctly -- is

Strawberry shortcake.

At major cardiology conference, Wegovy’s the word statnews.com/2024/09/02/eur… via Andrew Joseph

Hello and welcome back, everyone! 17 weeks until the end of the year. Let's hope they are packed with biotech action.

$DYN reports new results for DYNE-251, its DMD exon 51 skipper -- a potential competitor to $SRPT Exondys 51 -251 dosed at 20 mg/kg showed dystrophin expression 3.71% of normal via western blot, or 10-fold better than Exondys. "Meaningful improvements" in functional

Geesh, I missed the second $DYN announcement this morning: The CMO, COO and CBO (chief business officer )are also leaving. investors.dyne-tx.com/news-releases/…

Recursion $RXRX presents mixed data on lead AI-derived drug candidate for potentially fatal brain condition statnews.com/2024/09/03/rec… via Allison DeAngelis Safe, well tolerated. Efficacy? Not much at all.

Investment bankers weren’t working on Labor Day?

$DYN safety data

Diagnosed with cancer, a pharmaceutical executive became a patient advocate and changed drug development. It took decades statnews.com/2024/09/03/mul… Matthew Herper 's excellent profile of Kathy Giusti

Checking in on the stabilizer vs silencer debate: $BBIO +10% $ALNY flat

Vaxcyte $PCVX shares boom as one of biotech’s big David vs. Goliath stories heats up statnews.com/2024/09/03/vax… via Matthew Herper

Maybe there are no buyers for anything! 😳

Moderna reports encouraging results on its mpox vaccine, as outbreaks in Africa spread statnews.com/2024/09/04/mod… via Helen Branswell 🇨🇦 $MRNA

Can amylin drugs best Wegovy and Zepbound? Companies bet on next big obesity target $NVO $ZEAL statnews.com/2024/09/05/obe… via Elaine Chen Allison DeAngelis

Summit Therapeutics $SMMT vs. Merck $MRK: Prepping for a big lung cancer study reveal statnews.com/2024/09/05/sum… A look ahead at the HARMONi-2 study presentation on Sunday at #WCLC24

Vor Biopharma’s $VOR ‘shielded’ transplant delays relapse in leukemia patients statnews.com/2024/09/05/vor…

It's official: The Readout LOUD podcast has a new lineup of co-hosts. Elaine Chen (and her dry wit) joins Allison DeAngelis and me (our wits are less dry, and in my case, perhaps wit-less.) We're excited to have Elaine on board! ROL co-host is a pretty exclusive club. She's