The Cape Sounio EMBO meeting on "The DNA Damage Response in cell physiology and diseases" is now open for registration! 👇 Deadline May 17th! meetings.embo.org/event/24-dna-d…

Another #embotelo meeting in the books. See u back in Rome in 2026 ⁦

Huge thanks to Miguel Godinho Ferreira CMAzzalin Lab The Boulton Lab Maria Teresa Teixeira and GRAZIA Raffa for putting together a great meeting

So proud of our own Alessandra Brambati for winning the Tri-i breakout prize. Grande Ale! MSK ScienceEducation Memorial Sloan Kettering Cancer Center

Last chance to register for the 2024 EMBO Workshop on the DNA Damage Response in cell physiology and diseases! 💥👇

I rarely enjoy writing reviews as much as I did for this one. It was fun working with Mitch McVeylab and Marcel Marcel Tijsterman to try to document the chronicles of MMEJ in this Annual Reviews ARCDB go.shr.lc/3KG0DLX

It’s happening again! Mark your calendar 10 - 13 Jun 2025 and join us for the 2nd The ageing genome: from mechanisms to disease symposium embl.org/about/info/cou… via EMBL

Dear America, Lebanon has had no President for 2 years. Consider it. Take a break.

Thanks Julian Sale. It was an inspiring visit to the MRC Laboratory of Molecular Biology, and I love the swag!

Serendipity in science! Thanks NatureStructMolBiol, for the chance to write on the PolQ path to the clinic. It started by asking the how and the why. rdcu.be/dM437

We identified a complex network of proteins that regulate MMEJ:NHEJ repair pathway balance in a chromatin context-dependent manner. With impact on cancer genomes. Paper is finally out: nature.com/articles/s4146…

Excited to share our preprint "Multiome Perturb-seq unlocks scalable discovery of integrated perturbation effects on the transcriptome & epigenome". This work extends single-cell CRISPR screens to simultaneously profile gene expression & chromatin accessibility.

On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! nature.com/articles/s4158… We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. Lori Passmore David Rueda

Finally, my goal is that we use these powerful technologies to uncover new biology. Over the past 7 years, I have accumulated an inordinate amount of experience scrutinizing mtDNA variants that I would like to put to good use. So, here’s my offer: 6/n

If you have an mtDNA tracing dataset, regardless of the technology or stage of the project, I will review your workflow/results/interpretation within 1 week--provided the code and data are made available in public (e.g., GitHub) and discussion also occurs on a public forum. 7/n

So happy this is finally out. Fantastic collaboration with The Nogales Lab to obtain high resolution structure of the human NuA4/TIP60 complex and investigate the function of the TRRAP subunit in recruitment. science.org/doi/10.1126/sc…

Can we recreate the transcriptional states seen in single-cell atlas projects? In our new preprint we try to do this using large-scale Perturb-seq experiments. Along the way we discuss off-target effects of CRISPR epigenetic editors and identify drivers of key fibroblast states.

📢SAVE THE DATE: 7-10 July 2025 Agnel Sfeir , Karlene Cimprich & Chowdhury Lab are chairing the #BGFP25 which is taking place in wonderful Lisbon, Portugal next July.☀️ Registration is now OPEN, for more info and details on how to register, follow the 🔗: bit.ly/3AnsVZF