Hélène Vantomme (Sorbonne University) explores sex biases in thymic T cell repertoire generation and selection by comparing TCR repertoires across thymic subpopulations in men and women #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Romi Vandoren (University of Antwerp) introduces Adaptive Immune Receptor Repertoire-Wide Association Study (AIRRWAS), a framework to link TCR sequences to their target microbial species. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

airr_community iReceptor Gateway ImmunoMind. Teichlab Fred Hutchinson Cancer Center Great to catch up with airr_community colleagues at #AIRRC7. Thanks to those who came to the iReceptor Gateway deep dive tutorial and the discussions that followed. Looking forward to more collaborations...

Justin Barton (Alchemab Therapeutics), moderator of the “AIRR-C Challenge Session: Machine Learning applied to AIRR-seq data”, reviews the state-of-the-art of ML learning methods. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Keynote Speaker Jeffrey Gray (Johns Hopkins University) shares AI-based methods developed for antibody engineering, mostly based on antibody data sets. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Charlotte Deane (University of Oxford) describes some of the novel computational tools and databases developed by the Oxford Protein Informatics Group (OPIG). #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Niranjani Prasad (Microsoft Research) presents the Adaptive Immune Repertoire-Invariant Variational Autoencoder (AIRIVA), a generative model that learns a low-dimensional, interpretable, and compositional representation of TCR repertoires. #AIRRC7 Agenda: tinyurl.com/airrcmeeting7

Monica Fernandez-Quintero (The Scripps Research Institute) presents “Modelling Conformational Dynamics of Antibodies - Consequences for Biophysical Properties” #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Eve Richardson (La Jolla Institute for Immunology) presents “Methods for antigen-specificity prediction applied to BCR-seq data” #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Wing Ki Wong (Roche Diagnostics GmbH) discusses how integrating advanced language models, bioinformatics tools and antigen-mapped repertoires could accelerate the discovery and optimization of therapeutic antibodies. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Nina Luning Prak (University of Pennsylvania), starts the last day of #AIRRC7 with the Biomedical Science Session. Full agenda: tinyurl.com/airrcmeeting7

Keynote Speaker Hedda Wardemann (DKFZ) describes single-cell based antigen-receptor gene and function analyses to instruct optimized vaccine designs with a focus on malaria. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Ben Larman (Johns Hopkins University) discusses the limitations of high throughput antibody reactome profiling in “Antibody reactome profiling via self-assembling libraries of DNA barcoded antigens”. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Encarnita Mariotti-Ferrandiz (Sorbonne University) shows that peripheral blood TCR repertoires harbor information that can serve as biomarkers to enhance the diagnosis, prognosis, and management of inflammatory diseases. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Dmitriy Chudakov (Central European Institute of Technology) explores the connections between adaptive immunity functioning and malfunctioning in the context of modern immunotherapy. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Puneet Rawat (University of Oslo) presents “Understanding the role of T-cell receptor repertoire in T1D status”. #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Martin Pezous (Sorbonne-Université) shows how to leverage machine learning to analyze TCR repertoires in “The regulatory T-cell receptor repertoire as an early predictor of SLE disease progression and response to immunotherapy” #AIRRC7 Full agenda: tinyurl.com/airrcmeeting7

Vincent Van Deuren (University of Antwerp) analyzed the synovial fluid T-Cell Receptor (TCR) repertoire across different arthritis groups and T-cell subsets, to characterize the T-cells associated with HLA-B27 related spondyloarthropathies. #AIRRC7 tinyurl.com/airrcmeeting7

And the AIRR Community Service Prize goes to…. Pam Borghardt! Our 🫶AIRR Traffic Controller 🫶 and Executive Director. #AIRRC7 tinyurl.com/airrcmeeting7

Want to put (sensible!) error bars on your diversity estimate? In work now out Physical Review E I derive an analytical formula for unbiased sampling variance estimation thus removing the need for rarefaction analyses doi.org/10.1103/PhysRe…