How do prions replicate? How could there be replication but accelerated brain volume loss? Could the toxicity in prion diseases be from the rapid consumption of proteins, explaining the very low CSF Aβ42 levels in Creutzfeldt-Jakob disease? ncbi.nlm.nih.gov/pmc/articles/P…

Simon Mead Paul Jerome Lamont Ash Paul Lon S. Schneider, MD Jeff Browndyke Dan Clinton LogarithmicDis Nicolas Villain Seb Walsh Eric Widera, MD Jason Cohen LTCShop.com Robert Howard Madhav Thambisetty Kasper Planeta Kepp Trey Bateman Daniel Erskine shibley Alberto J Espay Timothy Daly, PhD Michael Schöll Vincent Planche Stefano L. Sensi Gill Livingston Ryan Townley Jesse F Ballenger (mastodon.world/@jfballenger) Jason Karlawish James Rupert Fletcher Adam M. Brickman Dr. Jennifer Manly Sarah Ackley, PhD Howard Gleckman Kathy Liu Richard Merrick Nancy Lundebjerg (she/her/hers) Nathaniel Chin Emmy Betz, MD, MPH 🇺🇲🩺🔬🤝❤️ Joanne Ryan Maggie Aime, BSN, RN | Freelance Writer Oskar Hansson David Jones Paul Thompson Ayisha Sharma Adam Dyer NHS England Welsh Government Health and Social Care NICE Andrew Joseph Ben Spencer Bad science is making clinical stories that are not rooted in a real biophysical mechanism. Bad science is inventing new entities & terminology because you didn't know the phenomenon already have a simpler physical explanation. Bad science leads to no translational benefits.

Joining the Movement Disorders Society was a no-brainer. One learns from many experts and nurtures lifelong friendships. Evidence for this latter benefit: Donald Gilbert & Hector Gonzalez in Mexico City (congreso.somma.org.mx) movementdisorders.org MDS

Un cierre magistral de parte del Prof Don Gilbert (⁦Donald Gilbert) para el⁩ congreso #SOMMA en la ciudad de México. Muchas perlas de conocimiento en español. Fuiste brillante, Don! 🙏🏻

To my Parkinson’s patients, with love: here is the video and transcript of my conversation with Davis Phinney FND’ Polly Dawkins about lumping vs splitting, rescue vs precision, and the promise and pitfalls of the new test for #Parkinsons (aSyn-SAA). davisphinneyfoundation.org/webinar-record…

Gavin Mogan (Gavin Mogan) is living proof of the power within people with Parkinson's. I loved this short video, in which my words on the subject served as a soundtrack to his 'impossible' feats. I love Gavin's fighting spirit. We all should nurture our inner Gavin!

Michael Okun nature Nature Reviews Disease Primers Braak's hypothesis, not his neuroanatomical study, has set our field back 20 years while Borghammer's radiological fantasy is so implausible it is easier to believe that the soul resides in the pineal gland

We became enamored by the ideas of Braak et al. and Borghammer et al. in no small part because of elegant figures. But if they don't reflect reality, they can't serve people with Parkinson's. Pathology ≠ pathogenesis Pathology ≠ degeneration Beware of pretty figures!

Poor outcomes after a "blood-thinning cocktail" for strokes (thrombolysis + anticoagulation/antiplatelet) suggest that strokes are not just the universal product of sticky blood. More can be less. Individualized etiology-targeted treatments are needed. nejm.org/doi/full/10.10…

To be a neurologist you need to be a good doctor, an enthusiastic teacher and a clinical researcher All 3 are possible but nowadays harder to achieve It is not enough to pleasantly follow guidelines and clock off. There are also occasions when you may need to break convention

Pathology as a sign of a normally reactive brain: In a mouse model, neurons with tau tangles showed 3-fold greater survival than those without tangles. Kudos to the Harvard University team for examining the central dogma of tau neurotoxicity in #Alzheimers. sciencedirect.com/science/articl…

Borghammer's brain-body dualism is as spurious as the brain-mind one. A population-based study found no cognitive or motor pattern separating the two. Can we finally move on, or will this myth prove as hard to kill as Braak's pareidolia? ANA Journals onlinelibrary.wiley.com/doi/10.1002/an…