Our new work uses GxDrug interaction to model genetic effects on drug response in cross sectional data. Includes a new method for GxE TWAS. There are important caveats, but we hope this is a step toward more precise treatments

Our study on utilizing smartphones to track behavior in real-time & predict depression severity is now out in Nature Digital Medicine.  Jonathan Flint Sriram Sankararaman Eran Halperin UCLA Depression Grand Challenge

Open TT faculty position at the department of medicine at the University of Chicago! Come join us in Genetic Medicine, Biomedical data science, Oncology, or any of the other sections. Apply here: academicjobs.uchicago.edu/positions/1318…

Great summary. Thank you Sasha :)

New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🎉 thank you all collaborators and reviewers! nature.com/articles/s4158…

Really cool paper that investigates (primarily mental health) phenotype imputation for GWAS as a trade-off between increased power versus decreased specificity. This gets at the broader conceptual question of what is a phenotype for? A few intriguing results/directions. 🧵:

Less than a week to #wcpg2023 , looking forward to seeing everyone there!

My lab is hiring postdocs to work on quantgen methods, EHR utilisation, disease heterogeneity and trajectories, if interested please DM, also happy to chat during the conference!

nacailab.com

Excited for the 2nd annual PhD Info session with UChicagoGGSB

Sign up at bit.ly/GeneticsInfo20… for application tips from a diverse panel of current PhD students and faculty! QuestBridge I'm First! LEDA Jack Kent Cooke Foundation Reach Higher Center for First-generation Student Success HSF Coca-Cola Scholars

The Department of Human Genetics at University of Chicago is searching for a faculty candidate in Computational genetic and genomics. Please share this job ad with your colleagues: apply.interfolio.com/127605

Very happy to see Minhui's paper out :) It was WAY more technically challenging than expected, scRNA data is complicated... But Minhui was up to the challenge, and we hope this is a step toward robust Gaussian variance component models for scRNA

Our new model of polygenic epistasis. We hope it's a helpful step toward precision medicine+understanding GWAS hits

It's crazy that David Tang did this as an undergrad. And very appreciative of key computational assist from jerome

I am very proud to share our work, titled: “Allele frequency differences of causal variants have a major impact on low cross-ancestry portability of PRS“,(medrxiv.org/cgi/content/sh…)

Interested in grad school in genetics? Check out this upcoming panel hosted by Human Genetics @ UChicago and UChicagoGGSB to learn about the application process and meet current students/faculty! 🧬

New preprint! In this paper Andy Dahl and I et al show how phenotype integration can improve GWAS power and PRS prediction for Major Depressive Disorder (MDD), and a new and simple metric for quantifying how specific these improvements are for MDD tinyurl.com/mry37nry
🧵 1/n

Come do a postdoc in statistical genetics with Xuanyao and me at Uchicago! Possible project areas include omnigenics, gene-context interaction, and/or more equitable genetic prediction. Please do reach out for a chat if you are interested :)

We have a new postdoc opening The University of Chicago! Interested in studying regulatory effects of genetic variants by using single cell genomics assays, CRISPR-based screens? Please apply! Please retweet!

My lab PioneerCampus @HelmholtzMunich is hiring!

We are looking for a postdoc interested in working on #singlecell and #spatial data to unravel the effects of chronic stress on neuronal gene expression and implications on psych disorders. DM enquiries welcome, pls RT!

tinyurl.com/34ck84dn

Much of this research is only relevant to specific genetic ancestries.
nature.com/articles/s4158…

An anthropologist, a geneticist, a philosopher and a historian of science walk into a bar ... OK, bad joke. We review a “The Genetic Lottery” by Kathryn Paige Harden in @lareviewofbooks. 1/10
lareviewofbooks.org/article/why-dn…

One of the most irresponsible pieces of science journalism I’ve seen. Paints the portrait of a savante-scientist…who courageously split from the rigorous (but boring) ideology of her mentor: “Let’s have an idea of what we’re talking about before making controversial claims.” 1/n