🧬Mega-GWAS for 2,068 traits among 635,969 Million Veteran Program participants Science Magazine‼️ 👉substantial non-European representation 👉26,049 variant-trait associations 📜science.org/doi/epdf/10.11… 📊browsable results: phenomics.va.ornl.gov/web/ (sum stats only in dbGAP)

Circadian timing🕒 is important for health, but circadian amplitude🏔️may be even more important. We found stronger core body temperature amplitude ➡️ more robust peripheral metabolite rhythms in humans. A robust clock organises the body's rhythms. nature.com/articles/s4159…

📢In a new study, the authors investigate the genetic associations between attention-deficit/hyperactivity disorder, cannabis use disorder and #cannabis use. #ADHD Ditte Demontis Aarhus University nature.com/articles/s4422…

What a stunning bug

🧬Univariate & multivariate GWAS of Nightingale metabolomics (249 metabolites) in UK Biobank (N=235,435) and Estonian Biobank (N=92,661) 👉14,837 loci (497 unique) 👉up to 75% of genetic variance explained 👉convergence on lipid homeostasis pathways 🔗medrxiv.org/content/10.110…

🤣🤣 Sitting on the step minding my own business and echidna train!! ❤️

Disentangling genetic risks for development and progression of Alzheimer’s disease | Brain | Oxford Academic academic.oup.com/brain/advance-…

This is super important for anyone using psychedelics to understand going in. Psychedelics reliably produce the *feeling* of insight. Doesn't make it true. Please read before disowning your family after that ayahuasca retreat. nature.com/articles/s4427…

How much good science is not happening these days because of the way credit gets distributed, which discourages scientists from collaborating in a true partnership?

Biobanks of predominantly non-European ancestry individuals From rdcu.be/dPZ9J

Very important to test Mendelian randomization associations in negative controls to exclude horizontal pleiotropy, when possible! 👉A PRS for smoking heaviness is associated with deprivation index and liking of cabbage (❗️) among never smokers 🚬->🥬 🔗onlinelibrary.wiley.com/doi/10.1002/ge…

Look how the leading causes of death in the US have changed over the past 4 years JAMA jamanetwork.com/journals/jama/…

A webserver (PGSFusion: pgsfusion.net), where you can upload GWAS summary stats and you receive: 👉polygenic risk scores (PRS) with 16 different methods 👉prediction performance statistics in UK Biobank preprint 📜: biorxiv.org/content/10.110…

A European Honey Buzzard Bird was fitted with a satellite tracking system. She started her flight in Reitz, Free State, South Africa on 20th April 2020 to reach Finland on the 2nd of June. Here is an image showing the data tracker which plots out the route that she took to

We know that DNA introgressed from one population into another is often deleterious, but why? Carl Veller and I show that stabilizing selection, by itself, can induce selection against introgressed ancestry. doi.org/10.1101/2024.0…

Major academic publishers' revenue and what they pay authors and reviewers: Revenue: Elsevier: $3.9 billion Springer Nature: $2 billion Taylor & Francis: $800M Wiley: $1.8 billion They pay: Academic authors: $0 Peer reviewers: $0

Happy science fact of the day: It's a year since the first Imaging Neuroscience paper was published, with 280 papers since then. Hence in just the first year, over half a million dollars has stayed within academia, rather than going to Elsevier [shareholders etc].

Just published: Our comprehensive review "Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice". 🥰🥳🧠 Enjoy a good scientific reading for the long weekend! #BipolarDisorder #Chronobiology #Sleep #Actigraphy

Listen now to the first episode of Light O'Clock's new season! Hosted by Carolina Guidolin with Orie Shafer as guest.