NEW RESEARCH! 👃🦠 A nasal commensal produces a broad-spectrum, short-lived antimicrobial peptide polyene that inhibits S. aureus in vitro and in vivo Andreas Peschel & colleagues nature.com/articles/s4156…

A perfect stocking stuffer for your chemical biologist: This season, decorate your mannose with fluorophores to make them glow! Mannose-specific labeling using our biosynthetic incorporation strategy out in JACS now. Way to go, So_Young Lee & Victoria Marando! pubs.acs.org/doi/full/10.10…

Breaking my long whatever-this-platform-is silence to begin putting out feelers to see who is looking for postdocs. Looking for: —Switzerland, Germany, UK {needs to have livable salary for US student loans, if such a position in the UK exists…}

Roses are red Violets are blue If you love Cryogenic Electron Microscopy This job ad is for you: jobs.brassring.com/1033/ASP/TG/ci…

Online now! Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors by Andrew N. Dates, Stephen C. Blacklow, and colleagues at Harvard Medical School Harvard Med BCMP Dana-Farber dlvr.it/T5NScW #chembiol

My work in Johannes Walter’s lab on developing a classifier to score AF-multimer predictions (alongside a large scale screening effort) is out as a preprint now! biorxiv.org/content/10.110… @Johanne23743184

just saw a marathon sign that said, “You didn’t have to run 26.2 miles just to get out of tissue culture,” and honestly i love boston sometimes

Roney (Ian Roney) & Rudner uncovered how bacteria prioritize the use of their lipid carrier for peptidoglycan synthesis. pubmed.ncbi.nlm.nih.gov/38683856/

Please RT: The Walter lab at Harvard seeks computational biologists to extend our work using AlphaFold to find new protein-protein interactions. Contact [email protected] biorxiv.org/content/10.110… predictomes.org

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/111798…

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Antibodies expand the scope of angiotensin receptor pharmacology | Nat Chem Biol doi.org/10.1038/s41589…

Very happy to share our new work out today in Science Magazine ! Truly a fascinating study and very surprising results! Congrats to all involved JK Lyu Nick Kapolka BryanRoth Brian Shoichet and many many others. science.org/doi/10.1126/sc…

Here's another troubling example of how bad Google AI Overviews can be. This overview on stem cells for knees is like an ad for unproven stem cell clinics & here again Google uses unproven clinics as its primary sources. Fact- there is no good evidence that stem cells help knees.

We're very excited to share that our paper on the 21-dehydroxylation of steroids is online in Cell today! Read how flatulence drives bacterial production of allopregnanolone, an FDA-approved drug for postpartum depression. Full-text here: authors.elsevier.com/a/1j8j7L7PXqQmM

We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. Edward Kalkreuter chun gui Nature Chemical Biology nature.com/articles/s4158…

saw this while leaving lab rn - unclear if the bird is saving the worm as a snack or if the worm managed to hide from the bird by mounting it?!?

I am ready to start protesting President Kamala Harris on January 20, 2025, but for the next few months, I’m coconut pilled x 1000. We have 100 days and change to stop an authoritarian right-wing demagogue hell bent on a pro-death agenda.

What about instead of making postdocs shorter we focus on making them better? More independent pay, benefits, etc? Similarly without more money it’ll mean fewer postdocs and an employer incentive to be efficient, but without an arbitrary axe at a time chosen by bureaucrats