Atrophy of what brain regions are selectively associated with α-synuclein pathology during preclinical stages? In this JAMA Neurology paper we found that the nucleus basalts of Meynert was in particular affected, which was related to impairment in executive function.

And the results of a small randomized trial vs Alzheimer's disease cnn.com/2024/07/30/hea… by Meg Tirrell —18% slower decline of cognitive function ~50% less brain shrinkage in relevant brain regions

Tegnells beundrare i USA Under helgen hölls den sortens massmöte där Anna Ekströms och FoHM:s tvångsmässiga frihetsbrölande har ett andra hem.

Catching up with Alzheimer's Society funded researcher Prof Paul Edison about today’s excellent presentation at Alzheimer's Association 👏 “Alzheimer’s Society funding enabled us to expand our liraglutide trial to over 200 people with early Alzheimer’s disease. I’m delighted to be sharing the

Our immediate past chair Jim Leverenz is up! Synuclein aggregate assay findings in the US Dementia with Lewy Bodies Consortium (an astonishing multisite effort led by Dr. Leverenz) are looking exciting indeed #AAIC24

The results of the UK GLP-1 receptor agonist liraglutide clinical trial in #Alzheimers has been presented at #AAIC24; N=204 (1:1 ratio) missed primary endpoint (change in the cerebral glucose metabolic rate), but showed 50% reduction in brain shrinkage reuters.com/business/healt…

.Werfen North America's GEM Premier 7000 with iQM3 has been named a 2024 #RD100 Awards Finalist in the Analytical/Test category. Congratulations!

Sweden's Truls Möregårdh was on the verge of defeat in the table tennis Olympic final and said he wanted to do something fun for the crowd. This is so good

Congratulations Eluned Morgan sworn in as the first female leader of Wales today. Baroness Morgan an alumna of UWC Atlantic has strong links with the College and principal Naheed Bardai was delighted to join her at the Senedd for this historical occasion. #UWCAalumni

Covid only affects people who don’t work out.

Interesting n=1 trial (pub in Nat Med) using an allele specific ASO to knock down a gain-of-function toxic protein in an ultrarare disease. nature.com/articles/s4159…

#PureMichigan with our #SpanishWaterDog Apollo by #LakeMichigan in #Macatawa.

Beautiful #RedMoon and red light at #BigRed lighthouse in #Macatawa #PureMichigan

Over 15 years ago this would have seemed incredible. Now the evidence is piling up! The 2008 reports of Lewy bodies inside neurons grafted in Parkinson’s disease certainly helped trigger our understanding of mechanisms underlying Parkinson’s disease progression.

It is perfectly reasonable to debate the extent to which prion mechanisms are shared across neurodegeneration and emerging evidence for human transmission of AD and CAA. What’s not ok - if we claim to be scientists - is to deny well established facts and experimental observations

Using U.S. Medicare admin. data from 2016 to 2020, researchers conduct a population-based cohort study & find that GLP-1 receptor agonists are significantly associated with a⬇️risk of #Parkinsons compared to the new use of DPP4 inhibitors in diabetics …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

This video will never stop being funny.

The abstract submission portal is now OPEN for Synuclein 2025. Hope you can join us and share your latest research! openingdoors.eventsair.com/syn/abstract

THEY'RE EATING THE DOGS

Wow! Trump is right, I just went to the 7-11 in Springfield, Ohio, to get some gas and a hot dog.