AI-based drug repurposing emerges as a compelling strategy to identify new indications for existing drugs for Alzheimer's disease. Read more in COSB #drugdiscovery #Alzheimers #ai sciencedirect.com/science/articl…

Check out our latest review on Pioneer Transcription Factors (TFs) by Manuel Carminati, Luca Vecchia, and Lisa Stoos in Current Opinion in Structural Biology Current Opinion/Research in Structural Biology! Read it here: doi.org/10.1016/j.sbi.…

Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A plat... sciencedirect.com/science/articl… Current Opinion/Research in Structural Biology Elsevier Biomedchem from Chiosis Lab #Omics #Interactomics #SystemsBiology #Proteomics

Very happy to get this paper out on our biophysical and SAXS studies of TrbB (doi.org/10.1016/j.crst…)! Congrats to Arnold Apostol on his first fiart-author publication! YorkU - Science Current Opinion/Research in Structural Biology

Anti-aging interventions need accurate biological age measurement. Machine learning "aging clocks" use diverse biomarkers to predict age. Check out recent advances in COSB #antiaging #MachineLearning sciencedirect.com/science/articl…

Since COVID-19 began in 2019, AI tools were developed for cost-effective, non-invasive, rapid diagnostics to help healthcare systems and control the virus. This review evaluates these AI techniques, aiming to prepare for future public health emergencies sciencedirect.com/science/articl…

AI advancements in de novo protein design enable the creation of novel proteins with specific functions, achieving up to 20% experimental success rates. Yet challenges remain in prioritizing designs and creating proteins with large conformational changes sciencedirect.com/science/articl…

3D protein structure is crucial for function. Machine learning models, like AlphaFold, have advanced protein structure prediction. Recent ML approaches also incorporate metals, co-factors, modifications, dynamics, and interactions, enhancing predictions sciencedirect.com/science/articl…

We are delighted to see our review come out in Current Opinion/Research in Structural Biology, where we review recent advances in the understanding of ion-driven rotary membrane motors.  Read it here:sciencedirect.com/science/articl… CPRatUCPH (1/5)

Read about new methods for predicting drug combination synergy using high-throughput screens. Since 2021, over thirty machine learning methods, mostly deep learning-based, have emerged. The best methods predict synergy well for known drugs or cell lines. sciencedirect.com/science/articl…

AI and high-content imaging (HCI) advance drug discovery through deep neural networks, enhancing data analysis, screening methods, and compound profiling. Rapid, cost-effective HCI experiments provide large datasets for AI, relevant for drug discovery. sciencedirect.com/science/articl…

It was fun to work with Andrea Cavalli EPFL in the role of Section Editor for Current Opinion/Research in Structural Biology thanks to all authors and reviewers for their collaboration. Hope you enjoy the issue and it serves useful reference for the covered topics and inspiration ahead authors.elsevier.com/a/1jdXY,LqArU0…

Happy to edit this issue with Tero Aittokallio Current Opinion in Structural Biology collection on Artificial Intelligence (AI) Methodologies in Structural Biology (2024) You can find your complete collection at  sciencedirect.com/special-issue/… Elsevier Biomedchem and @ COSB_CRSB

AI in neurology improves diagnosis and treatment of neuronal disorders, especially Alzheimer's: analyzing neuroimaging for early diagnosis, predicting progression, identifying high-risk patients, evaluating treatments, developing therapies #Alzheimers sciencedirect.com/science/articl…

AI is transforming drug discovery and disease treatment by leveraging high-volume, multimodal data. This special article collection highlights AI's role in diagnosing, identifying therapeutic targets, and designing new drugs. sciencedirect.com/science/articl…

Check out the new COSB article collection on Macromolecular Assemblies (2024) edited by Elena Papaleo and Kenneth D. Westover! sciencedirect.com/special-issue/…

New COSB paper highlights recent structural insights into ion-driven membrane motors, specifically rotary ATPases and 5:2 motors, focusing on their mechanisms of ion selectivity and torque generation sciencedirect.com/science/articl…

Cryo-electron tomography combined with AI-driven subtomogram analysis is advancing the 3D visualization of biological macromolecules in their native environment, enhancing resolution for drug discovery and enabling deeper insights into macromolecules sciencedirect.com/science/articl…

New COSB review highlights recent advancements in structural biology, focusing on integrative approaches and AI techniques that combine various computational and experimental methods to model complex biological systems with precise spatiotemporal accuracy! sciencedirect.com/science/articl…

COSB review discusses the emerging efforts to model full-length antibody structures, focusing on their conformational flexibility and highlighting integrative approaches that combine experimental and computational methods to map their complex structures sciencedirect.com/science/articl…