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Beyond matrix #stiffness: Dr. Ioannis Zervantonakis and colleagues discuss how the therapeutic response is impacted by ECM composition and stiffness, interstitial fluid pressure, and elevated mechanical forces. bit.ly/3DMQkSO

~ 20 years ago, many colleagues felt at the precipice of understanding general principles based on quantitative biological models. This expectation is reflected in many influential articles, including this @nature review by Hartwell et al. Where is this expectation now? .

Some thoughts on #AACRPan23 as the 🛫 from Boston: A: Huge 🙏🏽 to AACR staff for their dedication in getting a 700 attendee event organized. B: 🙌🏽 to Rosie Sears Chris Iacobuzio Yeh Lab #DreamTeam C: The future of #PancreaticCancer research is very very 💪🏽 D: We all ❤️ KRAS

Great work from Janel Kopp and Jim Johnson, PhD on hyperinsulinemia in PDAC initiation in Cell Metabolism Congrats to 1st author Anni Zhang who showed that insulin receptor in PanIN drives inflammation through digestive enzyme production in acinar cells! cell.com/cell-metabolis…

🧬 Our new study on how "Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response via AP1 dichotomy" is out now on bioRxiv 🎉! Collaborative work of Shiv K Singh & Lab and Barbara Grünwald labs 🧪 Let's dive into the key findings! 🧵

Branch-duct Intraductal Papillary Mucinous Neoplasm (#IPMN) with Low-grade Dysplasia (w/ KRAS/GNAS mutations preoperatively). Thick mucin obstructing the side branch of the main pancreatic duct causing #pancreatitis. #Pathology #pancreaticcancerawarenessmonth #PancPath #GIPath

Our new in collaboration with Jakob Nikolas Kather Narmin Ghaffari Laleh Qinghe ZENG Stefano Caruso study is out in Nature Communications ! use of AI for reclassication of liver cancer, highlights👇 EASLnews AASLD AMMF Fondation ARC ILCA IMRB-Mondor GHU APHP. Hôpitaux Universitaires Henri-Mondor UPEC

NEW content online! Decoding the basis of histological variation in human cancer dlvr.it/T0TsJw

Ikigai is a 🇯🇵 concept representing “a sense of purpose in life”. It has been suggested as one of the reasons for the longevity of 🇯🇵 people, and observational studies found reduced risk of mortality from all causes among individuals feeling more ikigai. sciencedirect.com/science/articl…

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…

Running your own lab (watch the whole 7 minutes, it's priceless)

Good CAF or bad CAF, that's the question! In our new paper Cancer Cell we use #imagingmasscytometry to unravel the prognostic effect of cancer-associated #fibroblast (CAF) heterogeneity&their effect on therapy in 1000+ Unispital_USZ lung cancer patients cell.com/cancer-cell/fu…

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint elifesciences.org/reviewed-prepr…

Patho-DBiT allows for spatially exploring a wide range of rich RNA biology (alternative splicing isoform, SNV mutation, non-coding RNAs, microRNAs, RNA dynamics, etc) with superior sensitivity from clinical archival FFPE tissue samples!!!

Happy Lunar New 2024

Happening now 9AM- 12:30PM! “Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma” #AACR2024 authored by our TeamLab members Julien Dilly, Shalek Lab, S. Chugh,S. Dougan, B. Wolpin, Jonathan A. Nowak, Peter Winter, A. Aguirre

It's out! We report 3D mapping of human pancreatic precancer and associated genetic alterations. With the brilliant Ashley Kiemen and Denis Wirtz . Tweetorial to follow soon. nature.com/articles/s4158…

NEW content online! Developmental origins shape the paediatric cancer genome dlvr.it/T6L4X9

We are delighted to celebrate Dr. Laurie Glimcher Laurie Glimcher MD , a valued member of our board, for her remarkable tenure as President and CEO, now President Emerita, of Dana-Farber. We also look forward to continued collaboration under the new leadership of Dr. Benjamin Ebert, a