PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis Ippei Shimizu Ippei Shimizu and coworkers embopress.org/doi/full/10.10…

The unfolded protein response regulates ER exit sites via SNRPB-dependent RNA splicing and contributes to bone development Loydie Jerome-Majewska Loydie McGill University, Hesso Farhan Hesso Farhan Med. Uni. Innsbruck and coworkers embopress.org/doi/full/10.10…

It was a pleasure to write this The EMBO Journal news and views about two wonderful papers from Tom Deegan and Karim Labib: embopress.org/doi/full/10.10… I highly recommend these papers. Thanks to Hartmut Vodermaier for the opportunity! 🫶🧪

Histone demethylase KDM2A recruits HCFC1 and E2F1 to orchestrate male germ cell meiotic entry and progression  embopress.org/doi/full/10.10…

Insulin-responsive GLUT4 secretion requires a designated clathrin isoform, CHC22, which is specifically recruited through its interaction with the trafficking proteins p115 and SNX5 Joshua Greig Joshua Greig Frances Brodsky et al embopress.org/doi/full/10.10…

Andreas Strasser, Gemma Kelly and colleagues WEHI (Walter and Eliza Hall Institute) present several new knock-in mouse models for the study of differential TP53 responses and contributions to apoptosis or cell-cycle arrest embopress.org/doi/full/10.10…

Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity Carol Thiele, Zhihui Liu et al embopress.org/doi/full/10.10…

Fission yeast CDK ensures proper chromosome distribution and faithful genome transmission into meiotic products by Swi5-Sfr1 restriction and Rad51 downregulation in late meiotic prophase Inés Palacios-Blanco, Cristina Martín-Castellanos et al embopress.org/doi/full/10.10…

Does the 9-year-old unifying hypothesis still hold–that an increased number of mutant myosin available for actin binding causes cardiac hypercontractility? Yes, say Ruppel, Spudich et al Stanford Medicine upon reviewing recent structural & enzymatic analyses! embopress.org/doi/full/10.10…

Genome-wide i-motif immunoprecipitation and next-generation sequencing shows that sequences capable of forming these knot-like DNA structures are widely distributed in human genomes and common in G0/G1-expressed genes Daniel Christ and coworkers embopress.org/doi/full/10.10…

STIC2 is a newly-identified interaction of ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins, in particular photosystem reaction center protein D1 Danja Schunemann and colleagues Ruhr-Universität Bochum embopress.org/doi/full/10.10…

Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence IRTKS contributes to the formation and maintenance of HP1α-driven heterochromatin condensates by promoting HP1α SUMOylation embopress.org/doi/full/10.10…

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma Peter Sims Peter Canoll Columbia University et al find quiescent astrocyte-like glioma cells show abnormal energy metabolism, sensitizing them to ferroptosis-inducing drugs embopress.org/doi/full/10.10…

A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth Björn von Eyss et al von Eyss lab Leibniz-Institut für Alternsforschung (FLI) embopress.org/doi/full/10.10…

Elucidating the assembly of gas vesicles by systematic protein-protein interaction analysis High-throughput in vivo screen by Manuel Iburg, Anderson, George Lu et al derives a comprehensive map of all eleven proteins of a microbial gas vesicle operon embopress.org/doi/full/10.10…

🚨 New paper in The EMBO Journal! The Karagöz lab has uncovered how IRE1, a crucial transmembrane protein, responds to protein folding stress in the ER and reveals that disordered regions in the luminal sensor domain play a vital role in its self-assembly ➡️ tinyurl.com/4jdm5p6x

We have a new paper for you: “Structure of tetrameric forms of the serotonin-gated 5-HT3A receptor ion channel”. Here we found that the prototypical pentameric ligand gated ion channel can form stable tetramers and characterized it with cryo-EM/ET and molecular simulations.

"Tetramers in the matrix" - this has got to be the first MUSICAL SYNOPSIS we ever had for an EMBO Journal article! Should become a more regular feature...

Issue 17 highlights: LINE1 stimulating host bone repair TNFR Wengen in tissue regeneration And… …PP2A governs cytokinetic abscission in Toxoplasma …CDK1 phosphorylation of TDP1 for repair of Top1-DNA complexes ... Sandra Krahl cover for Carmit Levy et al embopress.org/toc/14602075/4…

Disordered regions in the IRE1α ER lumenal domain form condensates in vitro and mediate its stress-induced clustering and signaling in cells Elif Karagöz Elif Karagöz Max Perutz Labs Vienna and coworkers embopress.org/doi/full/10.10…