If you work with #3Dgenome 3C+ data (Hi-C, Micro-C, ...), check out pairtools (biorxiv.org/content/10.110…)!

And we’re #hiring! abdenlab.org Attention #CompBio #postdoc candidates! We have projects focused on #3DGenomics, #Multiomics in human health, #aiml developing and applying both foundational infra and cutting-edge approaches. Apply here: ummsjobs.com/job/10102/

Happy to see out paper with Erica Hildebrand (Dekker Lab), Kirill Polovnikov Kirill and Job Dekker Job Dekker out in Mol Cell 4DNucleome . How do cells manage topology of their chromosomes? 0/3

1/ We are excited to release our new preprint: "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" biorxiv.org/content/10.110…

This work is the result of a long term equal collaboration between 4 labs: Bill Earnshaw, Anton Goloborodko (Anton Goloborodko @[email protected]), Leonid Mirny (Leonid Mirny), and Job Dekker (Job Dekker), and driven by Kumiko Samejima, Johan Gibcus, Sameer Abraham, Fernanda Cisneros-Soberanis.

Pairtools v1.1.0 is out on github and PyPI and will soon be released on bioconda! This release fixes a few major bugs introduced into sort and dedup in recent versions and thus is highly recommended for upgrading! Full release notes: github.com/open2c/pairtoo…

How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by Grace Bower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/

(1/16) Check out our Simon Gaudin paper tiny.cc/icuazz from the Canzio lab out in Science Magazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.

Excited to share our new paper Nature Communications. bit.ly/3WUkxbJ Single-nucleosome imaging reveals that condensins act as molecular crosslinkers, locally constraining nucleosomes to organize mitotic chromosomes. Nucleosome-nucleosome interactions constrain whole chromosomes.

How do you find a needle in a genomic haystack? Yeast yields some answers here, thanks to Xless Agnès Dumont, Nicolas Mendiboure, Jérôme Savocco, Daniel Jost et al. Free here for 50 days, or very similar preprint here: x.com/aurelepiazza/s… Enjoy!

📢 Good news for anyone who missed the #EMBLOmics deadline, we've now extended it until 9 September so make sure to get your abstract in before then! 🧬🙌🏻 👉🏾 Over 20 talks will be selected from abstracts, with a priority for early stage researchers. ➡️ s.embl.org/omx24-01

We’re opening a researcher position in my group for a machine learning-focused computational biologist! calicolabs.com/careers/?gh_ji…

Cohesin lives many lives during the loop extrusion process, each of them impacting genome folding What a creative way to interrogate molecular pathways, using mathematical modeling to piece together the puzzle of experimental measurements!

Check out this new model of the cohesin state dynamics by Geoff Fudenberg and Maxime TORTORA! It's simple, yet makes non-trivial predictions (b/c even such simple networks are hard for a human brain to grasp fully). This may well be the new "standard model" for the field to build on