Development of Better Aptamers: Structured Library Approaches, Selection Methods, and Chemical Modifications (Yingfu Li and co-workers) #AngewandteReview #openaccess Yingfu Li Connor Nurmi onlinelibrary.wiley.com/doi/10.1002/an…

Huge congrats to former PhD student Mikaël on this nice article! Congrats to all authors, particularly Fabrice. INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie sciencedirect.com/science/articl…

Very happy to share our article published in Chemistry on protected RNA nucleotides for enzymatic production of oligonucleotides. Huge congrats to Maëva! INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

Interested in mRNA vaccines? Chemical modifications? a fully funded postdoc position? Then you may want to have a look at our add: research.pasteur.fr/fr/job/increas…

Now out J. Am. Chem. Soc.: Xeno Nucleic Acids get a new base pair! 🧬Outstanding work by Hannah Depmeier during her PhD Stephanie Kath-Schorr! Department of Chemistry (University of Cologne) Universität zu Köln #XNA #TNA #NucleicAcids #ExpandedGeneticAlphabet 🧬🎉 pubs.acs.org/doi/abs/10.102…

Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student Hongyu Chen: rdcu.be/dB7ck and his cartoon illustration👇MIT Chemistry Broad Institute

An exciting new report in Nature Biotechnology from Xiao Wang’s team led by Hongyu Chen shows that mRNAs with branched poly-A tails yield much higher levels, and prolonged production, of the corresponding proteins compared with conventional single-tailed mRNA. This discovery

Very happy to share our pre-print in ChemRxiv on a new method for the preparation of short and long modified DNA sequences. Huge congrats to Nazarii SABAT 🇺🇦 ! Great collaboration with Roche INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie go.shr.lc/3vAZb9B

I’m very happy to share with you our work on a new method for the synthesis of modified oligonucleotides using DNA ligases. Very proud of the work I’ve put on here. Hollenstein group Structural Biology-Chemistry at Institut Pasteur CNRS Chimie Roche chemrxiv.org/engage/chemrxi…

Curious how oligonucleotides are made on scale and what the future holds? Check out our review with lovelockresearchgroup appearing today in Science Magazine : science.org/doi/10.1126/sc…

Very happy to have contributed a bit to this nice review on nucleic acid production published The Scientist INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie Genomes & Genetics the-scientist.com/enzymatic-dna-…

Very happy to share our Perspective article on controlled enzymatic synthesis of nucleic acids published Communications Chemistry . Congrats to Maëva and thank you Huijuan for the kind invitation! Structural Biology-Chemistry at Institut Pasteur INSTITUT PASTEUR CNRS Chimie Genomes & Genetics nature.com/articles/s4200…

Perspective by Hollenstein group, discussing recent progress in the controlled enzymatic synthesis of oligonucleotides (Structural Biology-Chemistry at Institut Pasteur @INC_CNRS @Institutpasteur) nature.com/articles/s4200…

I am thrilled to share that the paper presenting the results of my PhD has just been published in Nucleic Acids Res! Warm congratulations to all the co-authors ! I hope this work is a step toward the molecular diagnosis of Parkinson and other Synucleinopathies ! academic.oup.com/nar/advance-ar…

Very happy to share our article on the enzymatic modification of DNA with PDT agents published RSC Chemical Biology. Congrats to all authors, particularly Niogret Germain! Great collaboration with Gasser Group ! INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur pubs.rsc.org/en/content/art…

My short article covering an awesome paper on controlled enzymatic RNA synthesis by D. Wiegand et al (nature.com/articles/s4158…) is out in the News&Views section of Nature Biotechnology ! Many thanks to Iris Marchal for the kind invitation! nature.com/articles/s4158…

Enzymatic synthesis of RNA oligonucleotides - Hollenstein group #NBTNV go.nature.com/4d7wDVl

Research on enzymatic RNA synthesis has long been eclipsed by work on DNA — but a new method provides a leap forward for RNA #NBTNV go.nature.com/4d7wDVl rdcu.be/dOlVf

Super happy that our ligase-based method to produce modified DNA was published today Nature Communications Congrats to all, especially Nazarii SABAT 🇺🇦 ! Thanks to Roche and PEPR MolecularXiv for funding! INSTITUT PASTEUR Structural Biology-Chemistry at Institut Pasteur CNRS Chimie doi.org/10.1038/s41467…