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Welcome to the page of Prof. Harald Kolmar TU Darmstadt ! Here we will be posting recent publications and other news from our group - check out our website for more information: lnkd.in/eWaCJuF academia #academicresearch #proteinengineering #antibodies #innovation

#Antibodyhitdiscovery by panning experiments were performed for decades using phage display. We recently established a FACS-assisted, yeast surface display-based panning approach. Check out the publication here: lnkd.in/dhYhtFQ #research #antibodies #academicresearch

#OTD in 1982 laureate James Allison published a paper in the Journal of Immunology identifying the protein structure of the T cell receptor, a previously mysterious ignition switch for immune response. His research led to a new way to treat cancer by using our own immune systems

Immunogenic reactions against therapeutic antibodies can trigger immune responses in patients. Check out our review article in PEDS: Protein Engineering, Design & Selection where we cover advances to tackle the problem: lnkd.in/durcHtD #antibody #mAbs #immunogenicity #proteinengineering

New article by Kolmar Lab (TU Darmstadt): Engineering therapeutic antibodies for patient safety: tackling the immunogenicity problem academic.oup.com/peds/peds/arti…

Don't miss today's talk about dextramabs - a novel format for high-drug-load antibody conjugates at #FestofBiologics! #Antibodies #ADCs

We recently demonstrated a straightforward #humanization strategy of #chickenderived #antibodies utilizing #YeastSurfaceDisplay and #NextGenerationSequencing, paving the way for avian-derived #mAbs in #therapeutic settings. Read the full article here: lnkd.in/dBSjWsz

We report the generation of a chicken-derived biparatopic #commonlightchain #antibody targeting conformational epitopes on domain II and III of #EGFR by using an epitope binning-based #screening approach using #YSD, published in Frontiers - Immunology Dec 2020: frontiersin.org/articles/10.33…

PROXIDRUGS amongst the funded #Clusters4Future finalists. Congratulations to all involved! Let’s kick off a new era of drug & technology development in the Rhine Main region. BMBF, Goethe-Universität, Max Planck Institute of Biophysics, TU Darmstadt, Uni Heidelberg, #Zukunftscluster, proxidrugs.de

New Research: A Generic Strategy to Generate Bifunctional Two-in-One Antibodies by Chicken Immunization: Various formats of bispecific antibodies exist, among them Two-in-One antibodies in which each Fab arm can bind to two different… frontiersin.org/articles/10.33… #immunology

A new generation of cancer-preventing vaccines could wipe out tumors before they form. fcld.ly/l2sw0w9 #LongReads

The first chicken-derived two-in-one antibody was generated from immunised chickens without the need for further engineering approaches. Read the full story here: frontiersin.org/articles/10.33… #antibodies #cancertherapy #therapy #twoinone #chickens #bispecifics #yeastdisplay

New Research: Streamlining the Transition From Yeast Surface Display of Antibody Fragment Immune Libraries to the Production as IgG Format in Mammalian Cells frontiersin.org/articles/10.33… #bioengineering #biotech

Our latest publication in Frontiers - Molecular Biology is out, describing the use of a high-throughput yeast surface display-based screening method for the discovery of novel protein variants with stabilised binding pockets! frontiersin.org/articles/10.33…

Remembering the first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie. Curie was born #OnThisDay in 1867.

Newest #research on a novel type of #multispecific #antibodies is out now in Frontiers - Immunology, describing trispecific #Tcellengagers with built-in risk mitigation of cytokine release. Read more here: frontiersin.org/articles/10.33…

Stefania Carrara from the lab of Harald Kolmar TU Darmstadt is the winner of the Thesis Award🏆 of the Centre for Synthetic Biology @TUDarmstadt. Congratulations!

Welcome to the newly elected GBM Board (l.t.r): Harald Kolmar, Blanche Schwappach-Pignataro, ⁦Haucke lab⁩, Klaudia Giehl and Albert Sickmann! Great projects and ideas ahead 👍