THE BUFFALO BANDITS ARE NLL CUP CHAMPIONS! 🏆

Join me in battling #ALS by donating to the ALS Therapy Development Institute: als.net/donate. If you're unable to donate, spreading the word also helps - use the hashtag #ALS to help raise awareness and support the cause. Big shout out and much love to Maria and Jules!

New collection of articles to share for #neurotwitter on axonal biology, iPSCs, and disease modeling: biomed.news/bims-axbals/20…

🔬🤖Excited to share our new preprint on robust virtual staining of key organelles! biorxiv.org/content/10.110… ✨ Virtual staining and segmentation of nuclei and cell membranes in phase images can significantly accelerate image-based screens and developmental studies. 🔍 Current

Incredible work by Akaash Kumar, James Manton, DeriveryLab and many others. Their modular multispectral imaging concept allows to record simultaneously up to 8 channels at high frame rates. We're happy that our SPY probes could complement the FP based multi-organelle tagging!

There have been some exciting new articles to dig into on neuron cell biology and disease mechanisms this month. #NeuroTwitter biomed.news/bims-axbals Bims: Biomed News

Excited for another FENS meeting in Vienna! #FENS2024 Presenting our data on how intermediate targets communicate with axons via signaling filopodia aka #cytonemes during neural circuit formation. Will be presenting my poster on Friday, session 6 (PS06-28PM-350). See you there!😃

Axonal lysosomes of all different sizes are zipping around for this week's #MicroscopyMonday Campfire LUT by Kevin Terretaz

Here's an interesting preprint that probes a mechanism of H2O2-mediated axonal microtubule reorganization: biorxiv.org/content/10.110… I like their approach of using a "subtoxic" peroxide concentration to tease this out. *more articles here: biomed.news/bims-axbals

Came across this useful screen of various p62/SQSTM1 antibodies for WB, IP, and ICC: ncbi.nlm.nih.gov/pmc/articles/P… These projects often go underappreciated but end up playing a large role in guiding research groups when designing new assays.

CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function | bioRxiv biorxiv.org/content/10.110…

Happy to share our paper on long-term single-particle tracking in live neurons Nature Chemical Biology. We showed that the number of active dynein motors can switch stochastically during the long transport, and we resolved the molecular steps of dynein. nature.com/articles/s4158…

Kicking off the week with some new reading material: biomed.news/bims-axbals/20… This review on lysosomal tubulation really grabbed my attention: pubmed.ncbi.nlm.nih.gov/39083004/ #AxonalBiology #Neurobiology #Neurodegeneration

Protrudin promotes endosomal tubule fission and endosome-to-Golgi traffic 🔬. New research by Julia Kleniuk and Evan Reid is now available on BioRxiv. biorxiv.org/content/10.110…

Delighted to share the updated version of our #CellTracksColab paper published in PLOS Biology journals.plos.org/plosbiology/ar… Fantastic work by Estibaliz Gómez de Mariscal, PhD Hanna Grobe, Joanna Pylvänäinen Laura Xénard, Ricardo Henriques and Jean-Yves Tinevez

When we tried to monitor endocytosis from these pits, there was another surprise! They are super stable, staying for tens of minutes inside clearings, as shown by two-color TIRF-SIM of spectrin and clathrin along the AIS📽️

Axon adaptation to tension, out today Current Biology. authors.elsevier.com/a/1jlO93QW8S6G… Kudos to Sara! Thanks MAroso and Paulo de Castro Aguiar for the AxonStretcher, TSilva and pedro brites for membranes, J&CVieira for transcriptomics, and the younger crew i3S-Instituto de Investigação e Inovação em Saúde.

This is a really exciting assay: great work!

Some great articles to sift through this week: biomed.news/bims-axbals/20… I wanted to highlight another robust antibody characterization by the Laflamme group: pubmed.ncbi.nlm.nih.gov/39257448/ As someone who spent a lot of time optimizing HTT IPs in graduate school, this is phenomenal.

These iPSC-derived motor neuron kinetics really flaunt the dynamic neurite remodeling and outgrowth that occurs in culture🔬 Kinetics taken on a Cytation10 imager US BioTek Laboratories Agilent Technologies Agilent Life Science Inverted Teal LUT by Kevin Terretaz (simply the best!)